Intracellular Aluminium in Inflammatory and Glial Cells in Cerebral Amyloid Angiopathy: A Case Report.

Int J Environ Res Public Health 2019 04 24;16(8). Epub 2019 Apr 24.

The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, ST5 5BG, UK.

(1) Introduction: In 2006, we reported on very high levels of aluminium in brain tissue in an unusual case of cerebral amyloid angiopathy (CAA). The individual concerned had been exposed to extremely high levels of aluminium in their potable water due to a notorious pollution incident in Camelford, Cornwall, in the United Kingdom. The recent development of aluminium-specific fluorescence microscopy has now allowed for the location of aluminium in this brain to be identified. (2) Case Summary: We used aluminium-specific fluorescence microscopy in parallel with Congo red staining and polarised light to identify the location of aluminium and amyloid in brain tissue from an individual who had died from a rare and unusual case of CAA. Aluminium was almost exclusively intracellular and predominantly in inflammatory and glial cells including microglia, astrocytes, lymphocytes and cells lining the choroid plexus. Complementary staining with Congo red demonstrated that aluminium and amyloid were not co-located in these tissues. (3) Discussion: The observation of predominantly intracellular aluminium in these tissues was novel and something similar has only previously been observed in cases of autism. The results suggest a strong inflammatory component in this case and support a role for aluminium in this rare and unusual case of CAA.

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph16081459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518255PMC
April 2019
6 Reads

Publication Analysis

Top Keywords

unusual case
12
levels aluminium
8
rare unusual
8
aluminium
8
high levels
8
case caa
8
brain tissue
8
amyloid angiopathy
8
fluorescence microscopy
8
location aluminium
8
congo red
8
aluminium amyloid
8
aluminium-specific fluorescence
8
aluminium brain
8
glial cells
8
intracellular aluminium
8
cerebral amyloid
8
inflammatory glial
8
case
6
microscopy parallel
4

References

(Supplied by CrossRef)
Aluminium should now be considered a primary aetiological factor in Alzheimer’s disease
Exley et al.
J. Alzh. Dis. Rep. 2017

Similar Publications