Pathophysiological, Molecular and Therapeutic Issues of Nonalcoholic Fatty Liver Disease: An Overview.

Authors:
Simona Marchisello
Simona Marchisello
Garibaldi Hospital
Roberto Scicali
Roberto Scicali
University of Catania
Italy
Francesca Urbano
Francesca Urbano
University of Catania
Italy
Salvatore Piro
Salvatore Piro
University of Catania
Italy
Francesco Purrello
Francesco Purrello
Garibaldi Hospital
Italy
Agata Maria Rabuazzo
Agata Maria Rabuazzo
University of Catania
Italy

Int J Mol Sci 2019 04 20;20(8). Epub 2019 Apr 20.

Department of Clinical and Molecular Medicine, University of Catania, Catania 95100, Italy.

Nonalcoholic Fatty Liver Disease (NAFLD) represents the leading cause of liver disease in developed countries but its diffusion is currently also emerging in Asian countries, in South America and in other developing countries. It is progressively becoming one of the main diseases responsible for hepatic insufficiency, hepatocarcinoma and the need for orthotopic liver transplantation. NAFLD is linked with metabolic syndrome in a close and bidirectional relationship. To date, NAFLD is a diagnosis of exclusion, and liver biopsy is the gold standard for diagnosis. NAFLD pathogenesis is complex and multifactorial, mainly involving genetic, metabolic and environmental factors. New concepts are constantly arising in the literature promising new diagnostic and therapeutic tools. One of the challenges will be to better characterize not only NAFLD development but overall NAFLD progression, in order to better identify NAFLD patients at higher risk of metabolic, cardiovascular and neoplastic complications. This review analyses NAFLD epidemiology and the different prevalence of the disease in distinct groups, particularly according to sex, age, body mass index, type 2 diabetes and dyslipidemia. Furthermore, the work expands on the pathophysiology of NAFLD, examining multiple-hit pathogenesis and the role of different factors in hepatic steatosis development and progression: genetics, metabolic factors and insulin resistance, diet, adipose tissue, gut microbiota, iron deposits, bile acids and circadian clock. In conclusion, the current available therapies for NAFLD will be discussed.

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Source
https://www.mdpi.com/1422-0067/20/8/1948
Publisher Site
http://dx.doi.org/10.3390/ijms20081948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514656PMC
April 2019
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References

(Supplied by CrossRef)
The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases
Charlton et al.
Hepatology 2017

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