A cross-sectional survey on the seroprevalence of dengue fever in febrile patients attending health facilities in Cross River State, Nigeria.

Authors:
Okokon I Ita
Okokon I Ita
University of Calabar
Joseph Paul Hicks
Joseph Paul Hicks
Leeds Institute of Health Sciences
John Walley
John Walley
University of Leeds
United Kingdom

PLoS One 2019 22;14(4):e0215143. Epub 2019 Apr 22.

Nuffield Centre for International Health and Development, University of Leeds, Leeds, United Kingdom.

Background: In Nigeria, recent reports suggest that dengue viruses could be a major cause of acute fevers. We sought to make a cross-sectional estimate of the prevalence of current and previous dengue infections in patients presenting with fever to healthcare centres in Cross River State Nigeria.

Methodology/principal Findings: This cross-sectional health facility survey recruited persons with temperature ≥38°C. Dengue virus immunoglobulin M (IgM)/immunoglobulin G (IgG) antibody testing using Onsite Duo dengue Ag-IgG/IgM lateral flow immunoassay cassettes was done. Samples which tested positive were further confirmed using the RecombiLISA dengue IgM and IgG enzyme linked immunosorbent assay kits and classified into primary and secondary dengue infection. Malaria testing was carried out using microscopy. Between 4 January 2017 and 24 August 2017 a total of 420 participants were sampled across 11 health centres. The mean age was 34 (range = 1-99), 63% were female, 49% reported sleeping under a treated mosquito net in the past week and 44% reported taking an antimalarial prior to seeking care. The mean number of days fever was present prior to seeking care was 8, and many of the participants presented with symptoms indicative of respiratory or urinary tract infections. Testing indicated that 6% (95% CI: 2, 13; n = 24) had either a primary or secondary dengue infection with or without co-existing malaria, while 4% (95% CI: 2, 9; n = 16) had either a primary or secondary dengue infection without co-existing malaria. 52% (95% CI: 46, 58; n = 218) had a malaria infection with or without any dengue infection, and 50% (95% CI: 44, 57; n = 210) had a malaria infection without any dengue infection.

Conclusion: Our study confirms the presence of dengue at not insignificant levels in patients attending health centres with fever in this south eastern province of Nigeria. These data highlight the danger of the common presumption in this setting that fever is due to malaria. Surveillance for dengue is vital in this setting.

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215143PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476506PMC
April 2019
1 Read

Publication Analysis

Top Keywords

dengue infection
16
dengue
13
primary secondary
12
secondary dengue
12
95% primary
8
patients attending
8
attending health
8
infection dengue
8
co-existing malaria
8
river state
8
cross river
8
infection co-existing
8
malaria infection
8
health centres
8
prior seeking
8
seeking care
8
malaria
6
infection
6
fever
5
age range
4

References

(Supplied by CrossRef)
Dengue: a continuing global threat
MG Guzman et al.
Nature reviews microbiology 2010
Dengue
CP Simmons et al.
N Engl J Med 2012
Epidemiological implications of preferences of breeding sites of mosquito species in Midwestern Nigeria
GR Okogun et al.
Ann Agric Environ Med 2003
Economic and Disease Burden of Dengue in Mexico
EA Undurraga et al.
PLoS Negl Trop Dis 2015
Dengue 2 in eastern Senegal: serologic survey in simian and human populations. 1974–85
JF Saluzzo et al.
Bull Soc Pathol Extol Filiales 1986
Dengue Virus in Nigeria: Current status and future perspective
JA Ayukekbong et al.
Br j virol 2014
The effect of climate on Dengue virus infections in Nigeria
MM Baba et al.
New York Sci J 2011
Sero-prevalence of dengue type-3 Virus among patients with febrile illnesses attending a tertiary hospital in Maiduguri, Nigeria
AN Idris et al.
IntJ Med. Med. Sci 2013

Similar Publications