Drug discovery strategies for acute radiation syndrome.

Authors:
Prof. Vijay K Singh, Ph.D.
Prof. Vijay K Singh, Ph.D.
Uniformed Services University of the Health Sciences F Edward H├ębert School of Medicine
Associate Professor and Acting Chair
Radiation Biology
Bethesda, MD | United States
Thomas M Seed
Thomas M Seed
Armed Forces Radiobiology Research Institute
United States
Ayodele O Olabisi
Ayodele O Olabisi
Wichita State University
United States

Expert Opin Drug Discov 2019 Jul 22;14(7):701-715. Epub 2019 Apr 22.

b Scientific Research Department , Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences , Bethesda , MD , USA.

: There are at the minimum two major, quite different approaches to advance drug discovery. The first being the target-based drug discovery (TBDD) approach that is commonly referred to as the molecular approach. The second approach is the phenotype-based drug discovery (PBDD), also known as physiology-based drug discovery or empirical approach. : The authors discuss, herein, the need for developing radiation countermeasure agents for various sub-syndromes of acute radiation syndromes (ARS) following TBDD and PBDD approaches. With time and continuous advances in radiation countermeasure drug development research, the expectation is to have multiple radiation countermeasure agents for each sub-syndrome made available to radiation exposed victims. : The majority of the countermeasures currently being developed for ARS employ the PBDD approach, while the TBDD approach is clearly under-utilized. In the future, an improved drug development strategy might be a 'hybrid' strategy that is more reliant on TBDD for the initial drug discovery via large-scale screening of potential candidate agents, while utilizing PBDD for secondary screening of those candidates, followed by tertiary analytics phase in order to pinpoint efficacious candidates that target the specific sub-syndromes of ARS.

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Source
http://dx.doi.org/10.1080/17460441.2019.1604674DOI Listing
July 2019
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References

(Supplied by CrossRef)
Article in Drugs Today (Barc)
Farese AM et al.
Drugs Today (Barc) 2015

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