Outside the liver box: The gut microbiota as pivotal modulator of liver diseases.

Biochim Biophys Acta Mol Basis Dis 2019 May 6;1865(5):912-919. Epub 2018 Jul 6.

Sahlgrenska Academy, Institute of Medicine, Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, S-413 45 Gothenburg, Sweden. Electronic address:

The gut microbiota affects host physiology and has evolved as an important contributor to health and disease. Gut and liver are closely connected and communicate via the portal vein and the biliary system so the liver is constantly exposed to gut-derived bacterial products and metabolites. The intestinal barrier is important for maintaining physical and functional separation between microbes in the gut and the interior of the host and disruption of the barrier function can lead to bacterial translocation and increased leakage of bacterial metabolites. Liver diseases have been associated with dysbiotic changes in the gut microbiota and impaired gut barrier integrity, thus a future strategy to treat liver disease may be to target the gut microbiota and thereby restore the gut barrier function. This review will summarize and discuss studies that have shown a link between the gut microbiota and liver disease with the main focus on non-alcoholic fatty liver disease and alcoholic liver disease.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbadis.2018.07.004DOI Listing
May 2019
1 Read

Article Mentions


Provided by Crossref Event Data
twitter
Twitter:
April 23, 2019, 3:42 am EST
twitter
Twitter: MIcrobiotaMI
July 24, 2018, 3:53 am EST

Publication Analysis

Top Keywords

gut microbiota
20
liver disease
16
gut
9
liver
9
gut barrier
8
liver diseases
8
barrier function
8
disease
5
microbiota
5
maintaining physical
4
metabolites liver
4
leakage bacterial
4
bacterial metabolites
4
diseases associated
4
associated dysbiotic
4
barrier maintaining
4
microbiota impaired
4
changes gut
4
dysbiotic changes
4
increased leakage
4

Similar Publications