Primary cilium and brain aging: role in neural stem cells, neurodegenerative diseases and glioblastoma.

Ageing Res Rev 2019 Jul 18;52:53-63. Epub 2019 Apr 18.

Cellular Oncology Group, Biodonostia Health Research Institute, San Sebastian, Spain; CIBER de Fragilidad y Envejecimiento Saludable (CIBERfes), Madrid, Spain; IKERBASQUE, Basque Foundation, Bilbao, Spain. Electronic address:

Brain aging is characterized by a progressive loss of tissue integrity and function as a consequence of impaired homeostasis and regeneration capacities. The primary cilium is a highly conserved organelle that projects from the cell surface in a single copy in virtually all mammalian cell types including neural stem/progenitors cells and neurons. Increasing evidence in the last decade points out that primary cilium could be a relevant mediator of neural stem cell activity, neurogenesis, neuronal maturation and maintenance, and brain tumorigenesis. In this review, we summarize the current knowledge about primary cilia roles in these processes. There is currently sufficient background to propose that defective primary cilia contribute to age-related cognitive decline and brain tumor development due to their critical roles in cell cycle control and signaling transduction. This might have potential applications on therapy against age-associated brain diseases.

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15681637183030
Publisher Site
http://dx.doi.org/10.1016/j.arr.2019.04.004DOI Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
July 2019
12 Reads

Publication Analysis

Top Keywords

primary cilium
12
primary cilia
8
neural stem
8
brain aging
8
primary
5
brain
5
neurons increasing
4
cognitive decline
4
cells neurons
4
decline brain
4
stem/progenitors cells
4
evidence decade
4
points primary
4
decade points
4
neural stem/progenitors
4
age-related cognitive
4
increasing evidence
4
cell types
4
single copy
4
copy virtually
4

Similar Publications