Dual role of autophagy/mitophagy in chronic obstructive pulmonary disease.

Authors:
Shan Jiang
Shan Jiang
Massachusetts Institute of Technology
United States
Jing Sun
Jing Sun
Modern Research Center for Traditional Chinese Medicine
China
Nabijan Mohammadtursun
Nabijan Mohammadtursun
Huashan Hospital
China
Zhang Hu
Zhang Hu
Zhejiang University
China
Qiuping Li
Qiuping Li
Jiangnan University
China
Zhengxiao Zhao
Zhengxiao Zhao
Huashan Hospital
Hongying Zhang
Hongying Zhang
West China Hospital
China
Jingcheng Dong
Jingcheng Dong
Fudan University
China

Pulm Pharmacol Ther 2019 Jun 17;56:116-125. Epub 2019 Apr 17.

Department of Integrated Traditional Chinese and Western Medicine, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

Chronic obstructive pulmonary disease (COPD) is a common lung disease characterised by progressive, irreversible airflow limitation. Multiple regulatory pathways are involved in COPD pathogenesis. Emerging evidence from clinical and basic medical research has suggested that autophagy-a highly conserved catabolic process mediated under various cellular stress conditions-plays a role in the development and prognosis of COPD. Nevertheless, precise function of autophagy remains debatable owing to its beneficial as well as detrimental consequences. In this review, we summarised the 'double-edged sword' functions of autophagy in COPD and aimed to distinguish and classify these functions on the basis of various factors, such as different airway cell types and autophagy stimulators and modulators. Moreover, we determined the biological-functional consequences of autophagy. In particular, we discussed mitophagy-also termed mitochondrial autophagy-which is a critical process in cellular energy homeostasis. We hope that our findings will shed new light on future therapeutic strategies for COPD.

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Source
https://linkinghub.elsevier.com/retrieve/pii/S10945539183024
Publisher Site
http://dx.doi.org/10.1016/j.pupt.2019.04.002DOI Listing
June 2019
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