Neuroimaging Evidence for Right Orbitofrontal Cortex Differences in Adolescents With Emotional and Behavioral Dysregulation.

Authors:
Philip A Spechler
Philip A Spechler
Vermont Center on Behavior and Health
Bader Chaarani
Bader Chaarani
Amiens University Hospital
France
Catherine Orr
Catherine Orr
University of Melbourne
Australia
Scott Mackey
Scott Mackey
University of California
Tempe | United States
Stephen T Higgins
Stephen T Higgins
University of Vermont
Tobias Banaschewski
Tobias Banaschewski
Central Institute of Mental Health
Germany
Uli Bromberg
Uli Bromberg
Universitaetsklinikum Hamburg-Eppendorf
Germany

J Am Acad Child Adolesc Psychiatry 2019 Apr 17. Epub 2019 Apr 17.

University of Vermont, Burlington; Vermont Center on Behavior and Health, University of Vermont, Burlington.

Objective: To characterize the structural and functional neurobiology of a large group of adolescents exhibiting a behaviorally and emotionally dysregulated phenotype.

Method: Age 14 adolescents from the IMAGEN study were investigated. Latent class analysis (LCA) on the Strengths and Difficulties Questionnaire (SDQ) was used to identify a class of individuals with elevated behavioral and emotional difficulties ("dysregulated"; n=233) who were compared to a matched sample from a low symptom class (controls, n=233). Whole-brain gray matter volume (GMV) images were compared using a general linear model with 10,000 random label permutations. Regional GMV findings were then probed for functional differences from three functional magnetic resonance imaging (fMRI) tasks. Significant brain features then informed mediation path models linking the likelihood of psychiatric disorders (DSM-IV) with dysregulation.

Results: Whole-brain differences were found in the right orbitofrontal cortex (R.OFC; p<.05; k=48), with dysregulated individuals exhibiting lower GMV. The dysregulated group also exhibited higher activity in this region during successful inhibitory control (F=7.53, p<.05). Path analyses indicated significant direct effects between the likelihood of psychopathologies and dysregulation. Modeling the R.OFC as a mediator returned modest partial effects, suggesting the path linking the likelihood of an anxiety or conduct disorder diagnoses to dysregulation is partially explained by this anatomical feature.

Conclusion: A large sample of dysregulated adolescents exhibited lower GMV in the R.OFC relative to controls. Dysregulated individuals also exhibited higher regional activations when exercising inhibitory control at performance levels comparable to controls. These findings suggest a neurobiological marker of dysregulation and highlight the role of the R.OFC in impaired emotional and behavioral control.

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Source
https://linkinghub.elsevier.com/retrieve/pii/S08908567193026
Publisher Site
http://dx.doi.org/10.1016/j.jaac.2019.01.021DOI Listing
April 2019
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