Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions.

Authors:
Haroon Khan
Haroon Khan
Abdul Wali Khan University
Pakistan
Marcella Reale
Marcella Reale
University
Prof
Chieti | Italy
Hammad Ullah
Hammad Ullah
Abdul Wali Khan University Mardan
Antoni Sureda
Antoni Sureda
Universitat de les Illes Balears
Spain
Ying Wang
Ying Wang
CAS Key Laboratory of Functional Materials and Devices for Special Environments
Hong Kong
Zhang-Jin Zhang
Zhang-Jin Zhang
School of Chinese Medicine
Hong Kong
Jianbo Xiao
Jianbo Xiao
Shanghai Normal University
China

Biotechnol Adv 2019 Apr 18. Epub 2019 Apr 18.

Institute of Chinese Medical Sciences, State Key Laboratory of Quality Control in Chinese Medicine, University of Macau, Macau. Electronic address:

The anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent in various types of cancers. A number of polyphenols from a wide variety of dietary sources could upregulate p53 expression in several cancer cell lines through distinct mechanisms of action. The aim of this review is to focus the significance of p53 signaling pathways and to provide molecular intuitions of dietary polyphenols in chemoprevention by monitoring p53 expression that have a prominent role in tumor suppression.

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http://dx.doi.org/10.1016/j.biotechadv.2019.04.007DOI Listing

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April 2019
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