Increased expression of miR-155 correlates with abnormal allograft status in solid organ transplant patients and rat kidney transplantation model.

Authors:
Jiayu Liang
Jiayu Liang
Institute of Urology
Yongquan Tang
Yongquan Tang
University of Sydney
Australia
Zhihong Liu
Zhihong Liu
Jinling Hospital
China
Xianding Wang
Xianding Wang
Sichuan University
China
Zijun Zou
Zijun Zou
The First Affiliated Hospital of Sun Yat-sen University
China
Chuan Zhou
Chuan Zhou
Seattle Children's Research Institute
United States
Kan Wu
Kan Wu
Nanyang Technological University
Singapore

Life Sci 2019 Jun 17;227:51-57. Epub 2019 Apr 17.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address:

Aims: Increasing evidence has shown the diagnostic value of miR-155 in organ transplantation. The dysregulation of miR-155 is reported to be associated with development of acute or chronic complications in solid organ transplant recipients. Here, we summarized related evidence to explore the correlation between the dysregulation of miR-155 and various allograft dysfunction in transplant recipients, and verified the dynamic change of miR-155 level in acute rejection (AR) using a rat renal transplantation model.

Main Methods: Eligible studies were retrieved from PubMed, Embase, and Cochrane Library databases. A meta-analysis method was performed to evaluate the diagnostic value of miR-155 in transplant recipients. Furthermore, the F344-Lewis rat renal transplantation model was established to validate the dynamic change of miR-155 expression during AR.

Key Findings: A total of 275 transplant patients, including renal, heart, and lung transplantation from 6 studies were analysed. The pooled SEN of miR-155 was 0.87 (95% CI, 0.78-0.93), the pooled SPE was 0.76 (95% CI, 0.63-0.85), the pooled PLR was 3.6 (95% CI, 2.2-5.8), the pooled NLR was 0.17 (95% CI, 0.09-0.31), the pooled DOR was 17.31 (95% CI, 7.20-41.65) and pooled AUC was 0.89 (95% CI, 0.86-0.92). The rat renal transplantation model (n = 24) and control model (n = 15) were successfully established. Expression of miR-155 in plasma was significantly increased in 7 d and 9 d post-transplantation compared to the control group (P < 0.05), and was consistent with the dynamic change of AR degree.

Significance: miR-155 is a potential biomarker for monitoring the abnormal allograft status in solid organ transplantation.

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http://dx.doi.org/10.1016/j.lfs.2019.04.043DOI Listing
June 2019
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