Toward neuroimaging-based network biomarkers for transient ischemic attack.

Authors:
Yating Lv
Yating Lv
Max Planck Institute for Human Cognitive and Brain Sciences
Germany
Xiujie Han
Xiujie Han
Anshan Changda Hospital
Anshan Shi | China
Yulin Song
Yulin Song
Memorial Sloan-Kettering Cancer Center
Yu Han
Yu Han
Advanced Membranes and Porous Materials Center
China
Dan Zhou
Dan Zhou
Nanjing Medical University
China
Fuding Zhang
Fuding Zhang
School of Public Health
College Park | United States
Qiming Xue
Qiming Xue
Beijing Friendship Hospital
China

Hum Brain Mapp 2019 Apr 19. Epub 2019 Apr 19.

Institute for Brain Research and Rehabilitation, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, South China Normal University, Guangzhou, China.

Stroke is associated with topological disruptions of large-scale functional brain networks. However, whether these disruptions occur in transient ischemic attack (TIA), an important risk factor for stroke, remains largely unknown. Combining multimodal MRI techniques, we systematically examined TIA-related topological alterations of functional brain networks, and tested their reproducibility, structural, and metabolic substrates, associations with clinical risk factors and abilities as diagnostic and prognostic biomarkers. We found that functional networks in patients with TIA exhibited decreased whole-brain network efficiency, reduced nodal centralities in the bilateral insula and basal ganglia, and impaired connectivity of inter-hemispheric communication. These alterations remained largely unchanged when using different brain parcellation schemes or correcting for micro head motion or for regional gray matter volume, cerebral blood flow or hemodynamic lag of BOLD signals in the patients. Moreover, some alterations correlated with the levels of high-density lipoprotein cholesterol (an index related to ischemic attacks via modulation of atherosclerosis) in the patients, distinguished the patients from healthy individuals, and predicted future ischemic attacks in the patients. Collectively, these findings highlight the emergence of characteristic network dysfunctions in TIA, which may aid in elucidating pathological mechanisms and establishing diagnostic and prognostic biomarkers for the disease.

Download full-text PDF

Source
http://dx.doi.org/10.1002/hbm.24602DOI Listing
April 2019
2 Reads

Publication Analysis

Top Keywords

ischemic attack
8
brain networks
8
ischemic attacks
8
prognostic biomarkers
8
transient ischemic
8
diagnostic prognostic
8
functional brain
8
patients
5
brain parcellation
4
parcellation schemes
4
communication alterations
4
schemes correcting
4
remained unchanged
4
alterations remained
4
unchanged brain
4
motion regional
4
matter volume
4
volume cerebral
4
cerebral blood
4
gray matter
4

References

(Supplied by CrossRef)
Efficiency and cost of economical brain functional networks
Achard S. et al.
PLoS Computational Biology 2007
Imaging structural co‐variance between human brain regions
Alexander‐Bloch A. et al.
Nature Reviews Neuroscience 2013
Brain network interactions in health and disease
Barch D. M. et al.
Trends in Cognitive Sciences 2013
Small‐world brain networks revisited
Bassett D. S. et al.
The Neuroscientist 2017
Dynamic reconfiguration of human brain networks during learning
Bassett D. S. et al.
Proceedings of the National Academy of Sciences of the United States of America 2011

Similar Publications