Cardiovascular Risk in Type 1 Diabetes Mellitus.

Authors:
Jonathan Schofield
Jonathan Schofield
Royal Free and University College Medical School
United Kingdom
Jan Ho
Jan Ho
Sir Charles Gairdner Hospital
Nedlands | Australia
Handrean Soran
Handrean Soran
University of Manchester
United Kingdom

Diabetes Ther 2019 Apr 19. Epub 2019 Apr 19.

Cardiovascular Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9WU, UK.

Type 1 diabetes mellitus (T1DM) is associated with premature cardiovascular disease (CVD), but the underlying mechanisms remain poorly understood. The American Diabetes Association and the European Association for the Study of Diabetes recently updated their position statement on the management of type 2 diabetes mellitus (T2DM) to include additional focus on cardiovascular risk; improved management of risk factors in T1DM is also needed. There are important differences in the pathophysiology of CVD in T1DM and T2DM. Hyperglycaemia appears to have a more profound effect on cardiovascular risk in T1DM than T2DM, and other risk factors appear to cause a synergistic rather than additive effect, so achievement of treatment targets for all recognized risk factors is crucial to reducing cardiovascular risk. Here we discuss the evidence for addressing established cardiovascular risk factors, candidate biomarkers and surrogate measurements, and possible interventions.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13300-019-0612-8DOI Listing
April 2019
1 Read

Publication Analysis

Top Keywords

cardiovascular risk
20
risk factors
16
type diabetes
12
diabetes mellitus
12
t1dm t2dm
8
risk
7
cardiovascular
6
diabetes
5
pathophysiology cvd
4
profound cardiovascular
4
differences pathophysiology
4
cvd t1dm
4
appears profound
4
needed differences
4
t2dm hyperglycaemia
4
hyperglycaemia appears
4
management risk
4
additional focus
4
include additional
4
t2dm include
4

References

(Supplied by CrossRef)
Article in Diabetes Care
K Khunti et al.
Diabetes Care 2015
Article in Diabetes
AM Secrest et al.
Diabetes 2010
Article in Lancet Diabetes Endocrinol
RR Huxley et al.
Lancet Diabetes Endocrinol 2015
Article in Diabetes Care
SS Soedamah-Muthu et al.
Diabetes Care 2006
Article in N Engl J Med
M Lind et al.
N Engl J Med 2014
Article in Am J Cardiol
T Costacou et al.
Am J Cardiol 2007
Article in Br Med J (Clin Res Ed)
PH Winocour et al.
Br Med J (Clin Res Ed) 1987
Article in Diabetologia
MJ Davies et al.
Diabetologia 2018
Article in N Engl J Med
A Rawshani et al.
N Engl J Med 2017
Article in PLoS Med
SJ Livingstone et al.
PLoS Med 2012
Article in J Am Coll Cardiol
HM Colhoun et al.
J Am Coll Cardiol 2000

Similar Publications