Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study.

Authors:
Lucia Ballerini
Lucia Ballerini
Orebro University
Fergus N Doubal
Fergus N Doubal
University of Edinburgh
Julie Staals
Julie Staals
Maastricht University Medical Centre
Netherlands
Mike Allerhand
Mike Allerhand
University of Edinburgh
United Kingdom
Xin Wang
Xin Wang
Laboratory of Human Carcinogenesis
Bethesda | United States
Tom MacGillivray
Tom MacGillivray
University of Edinburgh
United Kingdom

Sci Rep 2019 Apr 19;9(1):6320. Epub 2019 Apr 19.

Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.

Research has suggested that the retinal vasculature may act as a surrogate marker for diseased cerebral vessels. Retinal vascular parameters were measured using Vessel Assessment and Measurement Platform for Images of the Retina (VAMPIRE) software in two cohorts: (i) community-dwelling older subjects of the Lothian Birth Cohort 1936 (n = 603); and (ii) patients with recent minor ischaemic stroke of the Mild Stroke Study (n = 155). Imaging markers of small vessel disease (SVD) (white matter hyperintensities [WMH] on structural MRI, visual scores and volume; perivascular spaces; lacunes and microbleeds), and vascular risk measures were assessed in both cohorts. We assessed associations between retinal and brain measurements using structural equation modelling and regression analysis. In the Lothian Birth Cohort 1936 arteriolar fractal dimension accounted for 4% of the variance in WMH load. In the Mild Stroke Study lower arteriolar fractal dimension was associated with deep WMH scores (odds ratio [OR] 0.53; 95% CI, 0.32-0.87). No other retinal measure was associated with SVD. Reduced fractal dimension, a measure of vascular complexity, is related to SVD imaging features in older people. The results provide some support for the use of the retinal vasculature in the study of brain microvascular disease.

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Source
http://www.nature.com/articles/s41598-019-42534-x
Publisher Site
http://dx.doi.org/10.1038/s41598-019-42534-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474900PMC
April 2019
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