Bone mineral density in patients with longstanding type 1 diabetes: Results from the Canadian Study of Longevity in Type 1 Diabetes.

Authors:
Omar N Alhuzaim
Omar N Alhuzaim
Endocrine and Metabolism Center
Lima | United States
Leif E Lovblom
Leif E Lovblom
Hospital and Lunenfeld Tanenbaum Research Institute
Toronto | Canada
Marina Cardinez
Marina Cardinez
Lunenfeld-Tanenbaum Research Institute
Daniel Scarr
Daniel Scarr
Lunenfeld-Tanenbaum Research Institute
Genevieve Boulet
Genevieve Boulet
Lunenfeld-Tanenbaum Research Institute
Toronto | Canada
Alanna Weisman
Alanna Weisman
University of Toronto
Toronto | Canada
Julie A Lovshin
Julie A Lovshin
Lunenfeld-Tanenbaum Research Institute

J Diabetes Complications 2018 Dec 22. Epub 2018 Dec 22.

Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. Electronic address:

Aim: It is currently unclear if longstanding type 1 diabetes (T1D) affects bone mineral density (BMD).

Methods: BMD measured by dual-energy X-ray absorptiometry and history of fragility fracture was determined in 75 T1D participants with ≥50 years of diabetes duration and 75 age- and sex-matched non-diabetic controls. BMD T-scores were determined for the lumbar spine (LS), total hip (TH) and femoral neck (FN).

Results: T1D participants had median diabetes duration of 54 [52, 58] years, 41 (55%) were females, and mean A was 7.3 ± 0.8%. T1D females had higher LS T-scores compared to female controls (-0.3 ± 1.2 vs. -1.1 ± 1.4, p = 0.014), lower FN T-scores (-1.5 ± 1.0 vs. -1.2 ± 0.9, p = 0.042) and more fragility fractures (7 (17%) vs. 1 (2%), p = 0.021). In T1D, higher A1c was associated with higher adjusted odds of fragility fracture (p = 0.006). T1D males and controls showed no difference in BMD or fractures.

Conclusions: There were no substantial differences in T-score between T1D and matched controls; however, T1D females showed higher BMD at the LS and possibly paradoxically higher fragility fractures compared to matched controls. These findings suggest that lower T-scores may not be associated with a history of fragility fracture in females with longstanding T1D and that other factors should be investigated.

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10568727183108
Publisher Site
http://dx.doi.org/10.1016/j.jdiacomp.2018.12.009DOI Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
December 2018
10 Reads
1.925 Impact Factor

Publication Analysis

Top Keywords

type diabetes
12
fragility fracture
12
t1d
9
lower t-scores
8
fragility fractures
8
t1d participants
8
history fragility
8
t1d females
8
females higher
8
diabetes duration
8
bone mineral
8
mineral density
8
matched controls
8
longstanding type
8
diabetes
5
controls
5
fragility
5
higher
5
58] years
4
fracturesconclusions substantial
4

Similar Publications