The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents.

Authors:
Melina Mitsiogianni
Melina Mitsiogianni
Northumbria University
United Kingdom
Georgios Koutsidis
Georgios Koutsidis
The University of Reading
United Kingdom
Nikos Mavroudis
Nikos Mavroudis
University of Reading
Dimitrios T Trafalis
Dimitrios T Trafalis
University of Patras
Greece
Sotiris Botaitis
Sotiris Botaitis
Democritus University of Thrace
Xanthi | Greece
Rodrigo Franco
Rodrigo Franco
Redox Biology Center
Lincoln | United States
Vasilis Zoumpourlis
Vasilis Zoumpourlis
Institute of Biology

Antioxidants (Basel) 2019 Apr 18;8(4). Epub 2019 Apr 18.

Department of Applied Sciences, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK.

Many studies have shown evidence in support of the beneficial effects of phytochemicals in preventing chronic diseases, including cancer. Among such phytochemicals, sulphur-containing compounds (e.g., isothiocyanates (ITCs)) have raised scientific interest by exerting unique chemo-preventive properties against cancer pathogenesis. ITCs are the major biologically active compounds capable of mediating the anticancer effect of cruciferous vegetables. Recently, many studies have shown that a higher intake of cruciferous vegetables is associated with reduced risk of developing various forms of cancers primarily due to a plurality of effects, including (i) metabolic activation and detoxification, (ii) inflammation, (iii) angiogenesis, (iv) metastasis and (v) regulation of the epigenetic machinery. In the context of human malignant melanoma, a number of studies suggest that ITCs can cause cell cycle growth arrest and also induce apoptosis in human malignant melanoma cells. On such basis, ITCs could serve as promising chemo-therapeutic agents that could be used in the clinical setting to potentiate the efficacy of existing therapies.

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Source
http://dx.doi.org/10.3390/antiox8040106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523696PMC

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April 2019
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