Oxygen Saturation and Perfusion Index-Based Enhanced Critical Congenital Heart Disease Screening.

Authors:
Heather Siefkes
Heather Siefkes
University of California
Laura Kair
Laura Kair
University of Iowa
Daniel J Tancredi
Daniel J Tancredi
UC Davis School of Medicine
United States
Lorena Garcia
Lorena Garcia
University of California
United States
Satyan Lakshminrusimha
Satyan Lakshminrusimha
University at Buffalo
Buffalo | United States

Am J Perinatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatrics, University of California, Davis, Sacramento, California.

Objective:  To determine if addition of perfusion index (PIx) to oxygen saturation (SpO) screening improves detection of critical congenital heart disease (CCHD) with systemic outflow obstruction.

Study Design:  We determined screening thresholds for PIx and applied these to a cohort of newborns with and without congenital heart disease (CHD).

Results:  A total of 123 normal and 21 CHD newborns (including five with critical systemic outflow obstruction) were enrolled. Four of these five critical systemic obstruction subjects passed SpO-based screen. Four out of these five subjects failed PIx-based screen. The sensitivity for detection of systemic obstruction CCHD when compared with healthy infants increased from 20% (95% confidence interval [CI]: 1-72%) with SpO screening alone to 80% (95% CI: 28-100%) with combined SpO-PIx screen. However, 2.44% of normal infants failed PIx screen.

Conclusion:  Addition of PIx to SpO screening may detect additional cases of CCHD and further research is necessary to come up with optimal screening thresholds.

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Source
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685445
Publisher Site
http://dx.doi.org/10.1055/s-0039-1685445DOI Listing
April 2019
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