Institute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center, 100191, Beijing, China.
Backgrounds: Previous studies had revealed that sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) rs12487736 polymorphism was associated with blood pressure (BP), but whether rs12487736 could interact with lifestyle behaviors on BP is unknown.
Methods: A case-control study with 1092 Chinese children was conducted.
Results: We found an interaction between rs12487736 and high calorie foods intake (fried chips/cakes/cookies) on systolic blood pressure (SBP) (P = 0.027), and rs12487736 was associated with SBP in the subgroup having high calorie foods at least once in the last week (b = 2.19, P = 0.025), but not in the subgroup not having high calorie foods. Also, interaction between protein intake (meat/fish/soy beans/egg) and rs12487736 on diastolic BP (DBP) was identified (P = 0.049); rs12487736 was associated with DBP in the subgroup consuming protein (meat/fish/soy beans/egg) Conclusions: Interactions or combined effects between SCAP and lifestyle behaviors on BP support the importance of promoting a healthy lifestyle in the children genetically predisposed to higher BP.
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