Interaction between lifestyle behaviors and genetic polymorphism in SCAP gene on blood pressure among Chinese children.

Authors:
Yi-de Yang
Yi-de Yang
1School of Public Health
Shuo Wang
Shuo Wang
Beijing Tiantan Hospital
China
Yang Wang
Yang Wang
Beijing Advanced Innovation Center for Food Nutrition and Human Health
China
Bin Dong
Bin Dong
School of Public Health
China
Hai-Jun Wang
Hai-Jun Wang
School of Public Health
China

Pediatr Res 2019 Apr 19. Epub 2019 Apr 19.

Institute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center, 100191, Beijing, China.

Backgrounds: Previous studies had revealed that sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) rs12487736 polymorphism was associated with blood pressure (BP), but whether rs12487736 could interact with lifestyle behaviors on BP is unknown.

Methods: A case-control study with 1092 Chinese children was conducted.

Results: We found an interaction between rs12487736 and high calorie foods intake (fried chips/cakes/cookies) on systolic blood pressure (SBP) (P = 0.027), and rs12487736 was associated with SBP in the subgroup having high calorie foods at least once in the last week (b = 2.19, P = 0.025), but not in the subgroup not having high calorie foods. Also, interaction between protein intake (meat/fish/soy beans/egg) and rs12487736 on diastolic BP (DBP) was identified (P = 0.049); rs12487736 was associated with DBP in the subgroup consuming protein (meat/fish/soy beans/egg)
Conclusions: Interactions or combined effects between SCAP and lifestyle behaviors on BP support the importance of promoting a healthy lifestyle in the children genetically predisposed to higher BP.

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41390-019-0402-zDOI Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
April 2019

Article Mentions


Provided by Crossref Event Data
twitter
Twitter:
April 19, 2019, 10:30 am EST

Publication Analysis

Top Keywords

blood pressure
12
calorie foods
12
high calorie
12
meat/fish/soy beans/egg
8
rs12487736 associated
8
chinese children
8
lifestyle behaviors
8
subgroup high
8
rs12487736
6
fried chips/cakes/cookies
4
systolic blood
4
p = 0027 rs12487736
4
sbp p = 0027
4
pressure sbp
4
intake fried
4
chips/cakes/cookies systolic
4
behaviors unknownmethods
4
1092 chinese
4
case-control study
4
unknownmethods case-control
4

Similar Publications