Fourier transform infrared spectroscopy research on subchondral bone in osteoarthritis.

Authors:
Yanfei Lu
Yanfei Lu
Institute of Occupational Medicine and Poisons Control
China
Juanjuan Fu
Juanjuan Fu
National Institute for Viral Disease Control and Prevention
China
Yongkang Zhu
Yongkang Zhu
Jiangsu Province Hospital of Traditional Chinese Medicine
China
Yuan Zhao
Yuan Zhao
Fudan University
China
Jianhua Yin
Jianhua Yin
Second Military Medical University

Spectrochim Acta A Mol Biomol Spectrosc 2019 Jul 11;218:243-247. Epub 2019 Apr 11.

Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China. Electronic address:

Osteoarthritis (OA) is not only related to the degradation of articular cartilage, but also possibly to the changes of subchondral bone. The purpose of this study was to assess whether specific differences could be resolved from bone composition, as also contributed to OA. These differences were assessed by using Fourier transform infrared spectroscopy (FTIRS). The main parameters including mineral content, carbonate content, crystallinity, collagen cross-linking ratio (XLR) and acid phosphate content were represented with characteristic peak integration. It was found that mineral and carbonate content varied significantly with depths at different OA stages. Mineral content increased with depth in healthy samples, while carbonate content showed opposite trend. The mineral content reduced obviously with OA duration, which was different with carbonate decreasing only at early stage of OA. In addition, the content of acid phosphate, collagen maturity (XLR) and crystallinity slight varied with the OA aggravation. Therefore, the changes in subchondral bone were significantly associated with cartilage degeneration and OA, the associated parameters should be targeted for OA therapies.

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13861425193039
Publisher Site
http://dx.doi.org/10.1016/j.saa.2019.04.020DOI Listing
July 2019
3 Reads

Publication Analysis

Top Keywords

carbonate content
12
mineral content
12
subchondral bone
12
transform infrared
8
acid phosphate
8
fourier transform
8
changes subchondral
8
infrared spectroscopy
8
content
8
depths stages
4
content varied
4
varied depths
4
stages mineral
4
depth healthy
4
samples carbonate
4
healthy samples
4
mineral carbonate
4
increased depth
4
content increased
4
represented characteristic
4

Similar Publications