The skeletal renin-angiotensin system: A potential therapeutic target for the treatment of osteoarticular diseases.

Authors:
Jingjing Zhao
Jingjing Zhao
East China Normal University
China
Hao Yang
Hao Yang
Sichuan University
China
Bo Chen
Bo Chen
Key Laboratory of Public Health Safety of Ministry of Education
China
Rui Zhang
Rui Zhang
Cancer Hospital of China Medical University
Houston | United States

Int Immunopharmacol 2019 Apr 16;72:258-263. Epub 2019 Apr 16.

Translational Medicine Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an 710054, China.

The classical renin-angiotensin system (RAS) is known to be a key regulator of blood pressure as well as fluid and electrolyte homeostasis. Additionally, it is now evident that components of the RAS are produced and act locally in many tissues, including liver, kidney, heart, lung, eye, bone, reproductive organ, adipose, and adrenal tissue, and these components are collectively known as tissue RAS. Recently, several studies have shown that local bone RAS is directly involved in bone metabolism, and activation of skeletal RAS plays an important role in bone diseases, such as osteoporosis, arthritis, and deterioration as well as in fracture healing. Based on the identification of RAS components in bone, we examined a new therapeutic approach to attenuate bone diseases through RAS inhibitors: renin inhibitor, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers. In this paper, we provide a systematic review of the skeletal RAS in the pathophysiology of bone diseases and the beneficial effect of RAS inhibitors on bone tissue.

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Source
http://dx.doi.org/10.1016/j.intimp.2019.04.023DOI Listing
April 2019
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