Multilayer nanoscale functionalization to treat disorders and enhance regeneration of bone tissue.

Authors:
Ana Marina Ferreira
Ana Marina Ferreira
University of Piemonte Orientale "A. Avogadro
Italy
Chiara Tonda-Turo
Chiara Tonda-Turo
Technical University of Catalonia
Spain
Elena Mancuso
Elena Mancuso
School of Mechanical and Systems Engineering
Piergiorgio Gentile
Piergiorgio Gentile
School of Clinical Dentistry
Sheffield | United Kingdom

Nanomedicine 2019 Apr 17;19:22-38. Epub 2019 Apr 17.

School of Engineering, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address:

The coatings application onto medical devices has experienced a continuous growth in the last few years. Medical device coating market is expected to grow at a CAGR of 5.16% to reach USD 10 million by 2023 due to the increasing geriatric population and the growing demand for continuous innovation. Layer-by-Layer (LbL) assembly represents a versatile method to modify the surface properties, in order to control cell interaction and thus enhance biological functions. Furthermore, LbL is environmentally friendly, able to coat all types of surfaces with the creation of homogenous film and to include and control the release of biomolecules/drugs. This feature review provides a critical overview on recent progresses in functionalizing materials by LbL assembly for bone regeneration and disorder treatment. An overview of emerging and visionary opportunities on LbL technologies and further combination with other existing methods used in biomedical field, is also discussed to evidence the new challenges and potential developments in bone regenerative medicine.

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Source
http://dx.doi.org/10.1016/j.nano.2019.03.009DOI Listing
April 2019
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