(-)-α-Bisabolol reduces nociception and trigeminal central sensitisation in acute orofacial neuropathic pain induced by infraorbital nerve injury.

Life Sci 2019 Jun 16;227:122-128. Epub 2019 Apr 16.

Faculty of Dentistry, University of Toronto, Canada; Deparment of Physiology, University of Toronto, Canada.

Neuropathic orofacial pain conditions represent a challenge to diagnose and treat. Natural substances are promising therapeutic options for the control of pain.

Aims: This study aimed to examine whether (-)-α-bisabolol (BISA), a natural terpene, can attenuate nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain.

Materials And Methods: Infraorbital nerve transection (IONX) or sham operation was performed in adult male rats. Head withdrawal thresholds as a measure of facial mechanical sensitivity were tested with von Frey monofilaments applied bilaterally to the facial vibrissal pad pre-operatively (baseline) and then post-operatively before and at 60, 120, 240 and 360 min after administration of vehicle control per oris (p.o.) or BISA (200 mg/kg p.o.) (n = 8/group). Effects of BISA or vehicle on the activity of nociceptive neurons recorded in the medullary dorsal horn (MDH) were tested on post - operative day 8-10. ANOVA followed by post-hoc Bonferroni tested for statistically significant differences (p < 0.05) across study groups and time points.

Key Findings: IONX animals (but not sham or naïve animals) showed post-operative facial mechanical hypersensitivity that was unaffected by vehicle. However, administration of BISA at post-operative day 7 significantly reversed the mechanical hypersensitivity in IONX rats; this effect lasted for at least 6 h. BISA also attenuated IONX-induced central sensitisation of MDH nociceptive neurons, as reflected in reversal of their reduced activation thresholds, increased responses to graded mechanical stimuli and enhanced spontaneous activity.

Significance: BISA may attenuate nociceptive behaviour and central sensitisation in a rat model of acute trigeminal neuropathic pain.

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00243205193028
Publisher Site
http://dx.doi.org/10.1016/j.lfs.2019.04.032DOI Listing
June 2019
9 Reads

Publication Analysis

Top Keywords

infraorbital nerve
8
central sensitisation
8
recorded medullary
4
sham operation
4
ionx sham
4
transection ionx
4
medullary dorsal
4
operation performed
4
performed adult
4
nociceptive neurons
4
head withdrawal
4
rats head
4
male rats
4
neurons recorded
4
adult male
4
nerve transection
4
methods infraorbital
4
360 min administration
4
sensitisation rodent
4
nociceptive behaviour
4

Similar Publications