Int J Biol Macromol 2019 Jul 17;133:354-364. Epub 2019 Apr 17.
Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nadu, India. Electronic address:
Fractures and injuries pertaining to bone tissue usually take prolonged periods for its natural healing. To overcome this problem, the field of bone tissue engineering (BTE) has acquired an efficient designing mechanism that incorporates cells, biomaterials and the corresponding growth factors to promote both osteogenesis as well as mineralization of the bone. Amidst the various techniques available for scaffold creation, electrospinning is considered superior as it paves the way for the creation of nanostructured scaffolds using biopolymers. Chitosan (CS) and Gelatin (Gel) are two of the cardinal natural biopolymers used in the field of biomaterials and tissue engineering. They can be used either exclusively or in combination with other biopolymers for the enhancement of bone regeneration. Hence, this review aims to render an elaborate study on the CS and Gel-based nanofibrous scaffolds with and without additional composites and the properties that they portray in terms of BTE.