Nanocrystalline cellulose: Preparation, physicochemical properties, and applications in drug delivery systems.

Authors:
Hadi Parsian
Hadi Parsian
Babol University of Medical Sciences
Iran
Maryam Majidinia
Maryam Majidinia
Tabriz University of Medical Sciences
Iran
Mahdi Rahimi
Mahdi Rahimi
University of Wisconsin-Madison
Madison | United States
Seyed Mostafa Mir
Seyed Mostafa Mir
Cellular and Molecular Biology Research Center
Hossein Samadi Kafil
Hossein Samadi Kafil
Drug Applied Research Center
Tabriz | Iran

Int J Biol Macromol 2019 Apr 17;133:850-859. Epub 2019 Apr 17.

Student Research Committee, Babol University of medical sciences, Babol, Iran; Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran. Electronic address:

Cancer is the leading cause of death all over the world and chemotherapy is an important approach to fight cancer, however, there are many obstacles against successful cancer chemotherapy such as development of multidrug resistance, poor solubility of chemotherapeutic agents and adverse side effects to healthy tissues. An important strategy to overcome these obstacles, is the use of nanotechnology. In recent years, natural polymers such as cellulose and its nanoform structure, nanocrystalline cellulose (NCC), have attracted the interest of researchers in the field of nanotechnology and specially drug delivery systems, due to biocompatibility and biodegradability of NCC. Cellulose is the most abundant natural biopolymer and changes to NCC by several chemical and mechanical methods. In this review, we mainly focus on the methods for production of NCC, physicochemical properties and medical applications of NCC (e.g. regenerative medicine, replacement of vascular grafts, tissue engineering, anti-bacterial/anti-viral applications, diagnosis and biosensing) with a special emphasize on drug delivery systems.

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Source
https://linkinghub.elsevier.com/retrieve/pii/S01418130193169
Publisher Site
http://dx.doi.org/10.1016/j.ijbiomac.2019.04.117DOI Listing
April 2019
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