Sweet cognition: The differential effects of glucose consumption on attentional food bias in individuals of lean and obese status.

Authors:
Ashley E Mason
Ashley E Mason
Osher Center for Integrative Medicine
Nashville | United States
Kinnari Jhaveri
Kinnari Jhaveri
University of California
United States
Carlos Almeida
Carlos Almeida
Departamento de Ciências Biológicas
Diana Alba
Diana Alba
National Institutes of Health
United States
Suneil K Koliwad
Suneil K Koliwad
Gladstone Institute of Cardiovascular Disease

Physiol Behav 2019 Jul 17;206:264-273. Epub 2019 Apr 17.

Center for Health and Community, Department of Psychiatry, UCSF, United States; Department of Medicine, Division of Cardiology, UCSF, United States. Electronic address:

In general, glucose consumption improves cognitive performance; however, it is unknown whether glucose specifically alters attentional food bias, and how this process may vary by BMI status. We hypothesized that glucose consumption would increase attentional food bias among individuals of obese BMI status more so than among individuals of lean BMI status. Participants (N = 35) completed the n-back, a working memory task modified to assess attentional food bias (ATT-Food), under fasting and glucose challenge conditions. We computed pre-post changes in ATT-Food, blood glucose and insulin (∆BG & ∆BI), and perceived task-stress (∆stress). After the second cognitive test and blood draw, participants ate lunch and completed a "taste test" of highly palatable foods, and we recorded food consumption. Pre-post changes in ATT-Food were greater among participants of obese (relative to lean) BMI status (F(1,33) = 5.108, p = .031). Greater ∆ATT-Food was significantly associated with greater ∆BG (r = .462, p = .007) and reduced ∆stress (r =-.422, p = .011), and marginally associated with greater taste-test eating (r =.325, p = .057), but was not associated with ∆BI. Our findings suggest that individuals of obese BMI status may exhibit "sweet cognition," as indexed by greater attentional food bias following glucose ingestion, relative to individuals of lean BMI status. Among individuals of obese BMI status, sweet cognition may arise from difficulty broadening attention toward non-food cues after consuming a high glucose load, thereby potentially perpetuating sugar consumption. If confirmed by further research, measures of sweet cognition may help identify individuals with a phenotype of risk for obesity and greater sugar consumption, who may benefit from tailored interventions.

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Source
https://linkinghub.elsevier.com/retrieve/pii/S00319384183094
Publisher Site
http://dx.doi.org/10.1016/j.physbeh.2019.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563839PMC
July 2019
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