Task-related hemodynamic responses are modulated by reward and task engagement.

Authors:
Bruss Lima
Bruss Lima
Laboratory of Cognitive Physiology
Yevgeniy B Sirotin
Yevgeniy B Sirotin
Columbia University
New York | United States
Aniruddha Das
Aniruddha Das
University of Chicago
United States

PLoS Biol 2019 Apr 19;17(4):e3000080. Epub 2019 Apr 19.

Department of Neuroscience, Columbia University, New York, New York, United States of America.

Hemodynamic recordings from visual cortex contain powerful endogenous task-related responses that may reflect task-related arousal, or "task engagement" distinct from attention. We tested this hypothesis with hemodynamic measurements (intrinsic-signal optical imaging) from monkey primary visual cortex (V1) while the animals' engagement in a periodic fixation task over several hours was varied through reward size and as animals took breaks. With higher rewards, animals appeared more task-engaged; task-related responses were more temporally precise at the task period (approximately 10-20 seconds) and modestly stronger. The 2-5 minute blocks of high-reward trials led to ramp-like decreases in mean local blood volume; these reversed with ramp-like increases during low reward. The blood volume increased even more sharply when the animal shut his eyes and disengaged completely from the task (5-10 minutes). We propose a mechanism that controls vascular tone, likely along with local neural responses in a manner that reflects task engagement over the full range of timescales tested.

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Source
http://dx.plos.org/10.1371/journal.pbio.3000080
Publisher Site
http://dx.doi.org/10.1371/journal.pbio.3000080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493772PMC
April 2019
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