Role of Aqueous Extract of the Wood Ear Mushroom, Auricularia polytricha (Agaricomycetes), in Avoidance of Haloperidol-lnduced Catalepsy via Oxidative Stress in Rats.

Authors:
Xiaohong Liu
Xiaohong Liu
School of Life Sciences
China
Rakesh Kumar Sharma
Rakesh Kumar Sharma
Institute of Nuclear Medicine and Allied Sciences
India
Anurag Mishra
Anurag Mishra
Suresh Gyan Vihar University
Asst. Professor
Jaipur, Rajasthan | India
Gaurav Gupta
Gaurav Gupta
School of Pharmacy
India
Mahaveer Singh
Mahaveer Singh
Birla Institute of Technology and Sciences Pilani

Int J Med Mushrooms 2019 ;21(4):323-330

School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, 302017, Jaipur, India.

Haloperidol-induced catalepsy is an animal model of a psychotic disorder that may be associated with neurodegeneration and free radical damage. Auricularia polytricha is effective in both prevention and treatment of numerous types of neurological disorders. In the present study, anticataleptic activity of aqueous extract of A polytricha (AEAP) at different doses (400 and 600 mg/kg, respectively, p.o.) was studied using haloperidol-induced (1 mg/ kg, i.p.) catalepsy in rats. Repeated treatment with haloperidol (1 mg/kg, i.p.) on each other day for 15 days (days 5, 10, and 15) significantly induced catalepsy in rats. The effect of AEAP at different doses (400 and 600 mg/kg, p.o.) on levels of superoxide dismutase, catalase, and glutathione reductase as well as inhibition of lipid peroxidation in the forebrain region was assessed. After 15 days of treatment, AEAP (400 and 600 mg/kg) significantly inhibited haloperidol-induced catalepsy. Treatment with AEAP (400 and 600 mg/kg) exhibited significant elevation in the levels of superoxide dismutase, catalase, and glutathione reductase as well as lipid peroxidation in the forebrain region compared to the haloperidol-treated group. The study concludes that AEAP (400 and 600 mg/kg) significantly protects animals against haloperidol-induced catalepsy.

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Source
http://dx.doi.org/10.1615/IntJMedMushrooms.2019030351DOI Listing
January 2019
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