Advanced Epithelial Ovarian Cancer: Do More Options Mean Greater Benefits?

Authors:
Sara Bouberhan
Sara Bouberhan
Yale Cancer Center
Meghan Shea
Meghan Shea
Beth Israel Deaconess Medical Center
Boston | United States
Stephen A Cannistra
Stephen A Cannistra
Beth Israel Deaconess Medical Center

J Clin Oncol 2019 Apr 19:JCO1900500. Epub 2019 Apr 19.

1 Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.

A healthy 51-year-old woman presented with increasing abdominal and pelvic pain. Computed tomography imaging of the abdomen and pelvis showed an 11.6-cm pelvic mass, retroperitoneal lymphadenopathy, right hydronephrosis, and mesenteric tumor deposits ( Fig 1A ). A serum CA-125 was elevated at 1,149 U/mL. She underwent primary surgical cytoreduction including hysterectomy, bilateral salpingo-oophorectomy, appendectomy, resection of pelvic tumor, omentectomy, and low anterior resection with colorectal anastomosis. Intraoperatively, she was noted to have bilateral ovarian masses, pelvic and para-aortic lymphadenopathy, and a 4-cm omental tumor; in addition, both the uterus and rectosigmoid colon had adherent tumor deposits. All gross tumor was resected during the procedure. Final pathology confirmed high-grade serous carcinoma of ovarian origin ( Fig 1B ) that was determined to be stage IIIC as a result of upper abdominal involvement with greater than 2-cm tumor deposits, as well as retroperitoneal lymph node involvement. She underwent germline genetic testing, which did not identify a mutation in the , , , , or genes. She presented for adjuvant chemotherapy after an optimal (R0) resection.

Download full-text PDF

Source
https://ascopubs.org/doi/10.1200/JCO.19.00500
Publisher Site
http://dx.doi.org/10.1200/JCO.19.00500DOI Listing
April 2019
4 Reads

Article Mentions


Provided by Crossref Event Data
twitter
Twitter:
May 12, 2019, 6:33 pm EST
twitter
Twitter:
April 28, 2019, 11:42 pm EST
twitter
Twitter:
April 27, 2019, 9:03 pm EST
twitter
Twitter:
April 27, 2019, 4:28 pm EST
twitter
Twitter:
April 27, 2019, 1:15 pm EST
twitter
Twitter:
April 27, 2019, 9:52 am EST
twitter
Twitter:
April 27, 2019, 3:28 am EST
twitter
Twitter:
April 27, 2019, 2:41 am EST
twitter
Twitter:
April 27, 2019, 2:23 am EST
twitter
Twitter:
April 26, 2019, 8:56 pm EST
twitter
Twitter:
April 26, 2019, 6:10 pm EST
twitter
Twitter:
April 26, 2019, 3:19 pm EST
twitter
Twitter:
April 26, 2019, 3:02 pm EST
twitter
Twitter:
April 26, 2019, 2:02 pm EST
twitter
Twitter:
April 26, 2019, 1:45 pm EST
twitter
Twitter:
April 26, 2019, 1:39 pm EST
twitter
Twitter:
April 26, 2019, 1:15 pm EST
twitter
Twitter:
April 26, 2019, 1:08 pm EST
twitter
Twitter:
April 26, 2019, 1:07 pm EST
twitter
Twitter:
April 26, 2019, 1:05 pm EST

Publication Analysis

Top Keywords

tumor deposits
12
tumor
6
4-cm omental
4
omental tumor
4
lymphadenopathy 4-cm
4
para-aortic lymphadenopathy
4
masses pelvic
4
pelvic para-aortic
4
tumor addition
4
uterus rectosigmoid
4
gross tumor
4
tumor resected
4
resected procedure
4
deposits gross
4
adherent tumor
4
rectosigmoid colon
4
colon adherent
4
addition uterus
4
ovarian masses
4
salpingo-oophorectomy appendectomy
4

Altmetric Statistics

Similar Publications