Rapid Construction of Fused Heteropolycyclic Aromatics via Palladium-Catalyzed Domino Arylations of Imidazopyridine Derivatives.

Authors:
Jianwei Han
Jianwei Han
Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis
Shanghai | China
Min Zhao
Min Zhao
School of Engineering
Lawrence | United States
Limin Wang
Limin Wang
Institute of Microbiology
China

Org Lett 2019 Apr 19. Epub 2019 Apr 19.

Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering , East China University of Science & Technology , 130 Meilong Road , Shanghai 200237 , China.

By using diaryliodonium salts, a novel approach of a palladium-catalyzed cascade of diarylation/intramolecular dehydrogenative coupling reaction has been developed in the synthesis of phenanthro-imidazopyridine fused heteropolycycles. The method can tolerate various substrates, and the target products were rapidly constructed in one pot. Furthermore, studies of the detailed reaction mechanism provide an insight into the C-H functionalization of 2-aryl-imidazopyridine derivatives and the C-C bond formations in the presence of palladium catalyst.

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http://dx.doi.org/10.1021/acs.orglett.9b00761DOI Listing
April 2019
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