Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial.

Authors:
Amy T Hutchison
Amy T Hutchison
University of Adelaide
Prashant Regmi
Prashant Regmi
Nepal Medical College
Gokarneshwor | Nepal
Jason G Fleischer
Jason G Fleischer
The Neurosciences Institute
United States
Gary A Wittert
Gary A Wittert
University of Adelaide
Adelaide | Australia
Satchidananda Panda
Satchidananda Panda
Regulatory Biology Laboratory
United States
Leonie K Heilbronn
Leonie K Heilbronn
Garvan Institute of Medical Research
Australia

Obesity (Silver Spring) 2019 May 19;27(5):724-732. Epub 2019 Apr 19.

Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.

Objective: This study aimed to assess the effects of 9-hour time-restricted feeding (TRF), early (TRFe) or delayed (TRFd), on glucose tolerance in men at risk for type 2 diabetes.

Methods: Fifteen men (age 55 ± 3 years, BMI 33.9 ± 0.8 kg/m ) wore a continuous glucose monitor for 7 days of baseline assessment and during two 7-day TRF conditions. Participants were randomized to TRFe (8 am to 5 pm) or TRFd (12 pm to 9 pm), separated by a 2-week washout phase. Glucose, insulin, triglycerides, nonesterified fatty acids, and gastrointestinal hormone incremental areas under the curve were calculated following a standard meal on days 0 and 7 at 8 am (TRFe) or 12 pm (TRFd).

Results: TRF improved glucose tolerance as assessed by a reduction in glucose incremental area under the curve (P = 0.001) and fasting triglycerides (P = 0.003) on day 7 versus day 0. However, there were no mealtime by TRF interactions in any of the variables examined. There was also no effect of TRF on fasting and postprandial insulin, nonesterified fatty acids, or gastrointestinal hormones. Mean fasting glucose by continuous glucose monitor was lower in TRFe (P = 0.02) but not TRFd (P = 0.17) versus baseline, but there was no difference between TRF conditions.

Conclusions: While only TRFe lowered mean fasting glucose, TRF improved glycemic responses to a test meal in men at risk for type 2 diabetes regardless of the clock time that TRF was initiated.

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Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/oby.22449
Publisher Site
http://dx.doi.org/10.1002/oby.22449DOI Listing
May 2019
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References

(Supplied by CrossRef)
Intermittent fasting modulation of the diabetic syndrome in sand rats. II. In vivo investigations
Belkacemi L et al.
Int J Mol Med 2010

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