Parental height modifies the association between linear growth and neurodevelopment in infancy.

Authors:
Ravi Prakash Upadhyay
Ravi Prakash Upadhyay
All India Institute of Medical Sciences
India
Ingrid Kvestad
Ingrid Kvestad
University of Bergen
Norway
Mari Hysing
Mari Hysing
University of Bergen
Norway
Manjeswori Ulak
Manjeswori Ulak
Institute of Medicine
Norway
Suman Ranjitkar
Suman Ranjitkar
Institute of Medicine
Merina Shrestha
Merina Shrestha
Swedish University of Agricultural Sciences
Sweden
Laxman Shrestha
Laxman Shrestha
Institute of Medicine

Acta Paediatr 2019 Apr 19. Epub 2019 Apr 19.

Department of Research, Innlandet Hospital Trust, Lillehammer, Norway.

Aim: To estimate the extent to which maternal and paternal height modify the association between length-for-age Z-score (LAZ) and neurodevelopmental outcomes assessed by the Bayley Scales of Infant and Toddler Development, 3rd Edition (Bayley-III).

Methods: Baseline data from a clinical trial in 600 Nepalese infants aged 6-11 months with LAZ less than -1 were utilized. The primary exposure was the LAZ score, interaction variables were maternal and paternal height and the outcomes were Bayley-III cognitive, language and motor scaled scores. Linear regression and generalized additive model (GAM) were used to identify potential interactions.

Results: Linear regression analysis stratified by parental height categories showed that association between unit increase in LAZ and cognitive scaled score differed across maternal (normal height: ß 1.16, 95% CI; 0.75, 1.57 and short height: ß 0.67, 95% CI; 0.28, 1.05) and paternal (normal height: ß 1.32, 95% CI; 0.91, 1.72 and short height: ß 0.61, 95% CI; 0.03, 1.18) height categories. Maternal height also modified the association between LAZ and fine motor scaled score.

Conclusion: The association between LAZ and neurodevelopmental outcomes was attenuated when maternal and paternal height was taken into account. Parental stature should be considered when using LAZ as a proxy for neurodevelopment among infants. This article is protected by copyright. All rights reserved.

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Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/apa.14820
Publisher Site
http://dx.doi.org/10.1111/apa.14820DOI Listing
April 2019
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