Neural and neuronal discoordination in schizophrenia: From ensembles through networks to symptoms.

Authors:
Iveta Fajnerova
Iveta Fajnerova
Institute of Physiology
Czech Republic
Jiri Horacek
Jiri Horacek
Charles University in Prague
Czech Republic
Eduard Kelemen
Eduard Kelemen
State University of New York
United States
Jan Svoboda
Jan Svoboda
Institute of Molecular Genetics
Czech Republic
Ales Stuchlik
Ales Stuchlik
Institute of Physiology
Chennai | India

Acta Physiol (Oxf) 2019 Apr 19:e13282. Epub 2019 Apr 19.

Department of Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.

Despite the substantial knowledge accumulated by past research, the exact mechanisms of the pathogenesis of schizophrenia and causal treatments still remain unclear. Deficits of cognition and information processing in schizophrenia are today often viewed as the primary and core symptoms of this devastating disorder. These deficits likely result from disruptions in the coordination of neuronal and neural activity. The aim of this review is to bring together convergent evidence of discoordinated brain circuits in schizophrenia at multiple levels of resolution, ranging from principal cells and interneurons, neuronal ensembles and local circuits, to large-scale brain networks. We show how these aberrations could underlie deficits in cognitive control and other higher order cognitive-behavioural functions. Converging evidence from both animal models and patients with schizophrenia is presented in an effort to gain insight into common features of deficits in the brain information processing in this disorder, marked by disruption of several neurotransmitter and signalling systems and severe behavioural outcomes.

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Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/apha.13282
Publisher Site
http://dx.doi.org/10.1111/apha.13282DOI Listing
April 2019
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