Could hepatitis B vaccine act as an adjuvant to lower risk and relapses of cancer?

Authors:
Meric A Altinoz
Meric A Altinoz
Neuroacademy Group
Turkey
Aysel Ozpinar
Aysel Ozpinar
School of Medicine
Baltimore | United States
Alp Ozpinar
Alp Ozpinar
University of California at Davis
United States
Ilhan Elmaci
Ilhan Elmaci
School of Medicine
Baltimore | United States

Clin Exp Pharmacol Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, Acibadem University, İstanbul, Turkey.

In this review article, we hypothesize that Hepatitis B Virus Vaccine (HBV-V) and certain antigens of Hepatitis B Virus (HBV) could act as anticancer immunoadjuvants in addition to their role of preventing HBV-associated liver cancer. Evidence suggests that in animal breast cancer and melanoma models, combining hepatitis B-surface antigen (HBsAg) with other cancer antigens resulted in enhanced antitumour activity. HBsAg shares antigenic mimicry with healthy and malignant cells including squamous epithelia, thymic epithelia, bladder- and colon cancer cells. There exist anecdotal reports and small case series about spontaneous remission of leukaemias and neuroblastoma following acute HBV-infection. Recent studies also exist showing HBV-carrier state is a good prognostic factor for intrahepatic cholangiocarcinoma. Further epidemiological studies and animal experiments are necessary whether HBV-Vs exert additional immunoadjuvant benefits besides lowering the risk of liver cancer.

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/1440-1681.13
Publisher Site
http://dx.doi.org/10.1111/1440-1681.13096DOI Listing
April 2019
7 Reads

Publication Analysis

Top Keywords

hepatitis virus
8
liver cancer
8
cancer
5
hbsag shares
4
activity hbsag
4
good prognostic
4
antitumour activity
4
state good
4
mimicry healthy
4
hbv-carrier state
4
hepatitis
4
antigenic mimicry
4
shares antigenic
4
enhanced antitumour
4
prognostic factor
4
combining hepatitis
4
factor intrahepatic
4
melanoma models
4
intrahepatic cholangiocarcinoma
4
cancer melanoma
4

Similar Publications