Aspirin reduced recurrent stroke risk in patients with lacunar stroke.

Authors:
Tao Kong
Tao Kong
Suzhou Institute of Nano-Tech and Nano-Bionics
China
Jingzhou Chen
Jingzhou Chen
Chinese Academy of Medical Sciences and Peking Union Medical College
China
Kai Sun
Kai Sun
The University of Hong Kong
Hong Kong
Weili Zhang
Weili Zhang
Oklahoma State University
United States
Jizheng Wang
Jizheng Wang
Fuwai Hospital
China
Lei Song
Lei Song
State Key Laboratory of Proteomics
China
Daowen Wang
Daowen Wang
Institute of Genetics and Developmental Biology
China
Rutai Hui
Rutai Hui
Chinese Academy of Medical Sciences and Peking Union Medical College
China

Acta Neurol Scand 2019 Apr 19. Epub 2019 Apr 19.

Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Objectives: Lacunar stroke had an unfavorable prognosis in the long term with a high risk of recurrent stroke, aspirin has been widely used to prevent ischemic stroke, but data on the effect of antiplatelet therapy on lacunar infarction are limited. We investigated the long-term effect of aspirin treatment on stroke recurrence risk in patients with lacunar stroke in a multicenter prospective cohort.

Methods: Between November 2000 and November 2001, 2000 consecutive stroke patients (age 35-74 years) were recruited from seven clinical centers. For the present study, a total of 544 patients with lacunar infarction were finally included in the analysis. The patients were divided into two groups (aspirin group, n = 342 and non-aspirin group, n = 202).The effect of aspirin on stroke recurrence was evaluated by using Kaplan-Meier analysis and Cox regression models.

Results: During a median 4.1-year follow-up for 544 patients with lacunar stroke, 99 recurrent strokes, 125 major vascular events (stroke, myocardial infarction, and vascular death), 31 vascular deaths, and 59 all-cause deaths were identified. Kaplan-Meier analysis showed that aspirin non-users had a higher risk of future recurrent stroke and of vascular events than did aspirin users (log-rank test, P = 0.049, 0.047, respectively). Aspirin significantly reduced the stroke recurrence in patients with lacunar stroke analyzed with multivariate stepwise analysis using model of Cox proportional hazards with backward elimination (HR = 0.67, 95% CI 0.45-0.99).

Conclusion: We concluded that aspirin significantly reduced stroke recurrence in patients with lacunar stroke.

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Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.13105
Publisher Site
http://dx.doi.org/10.1111/ane.13105DOI Listing
April 2019
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References

(Supplied by CrossRef)
Silent brain infarcts: a systematic review
Vermeer SE et al.
Lancet Neurol 2007

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