Serologic Prevalence of Ebola Virus in Equatorial Africa.

Authors:
Imke Steffen
Imke Steffen
Hannover Medical School
Germany
Kai Lu
Kai Lu
National University of Singapore
Singapore
Lauren K Yamamoto
Lauren K Yamamoto
Blood Systems Research Institute
San Francisco | United States
Nicole A Hoff
Nicole A Hoff
UCLA School of Public Health
United States
Prime Mulembakani
Prime Mulembakani
University of California
United States
Jean-Jacques Muyembe-Tamfum
Jean-Jacques Muyembe-Tamfum
Institute of Tropical Medicine
Belgium
Nicaise Ndembi
Nicaise Ndembi
Institute of Human Virology
Nigeria

Emerg Infect Dis 2019 May;25(5):911-918

We conducted a serologic survey of 2,430 serum samples collected during 1997-2012 for various studies to determine the prevalence of the hemorrhagic fever virus Ebola virus (EBOV) in equatorial Africa. We screened serum samples for neutralizing antibodies by using a pseudotype microneutralization assay and a newly developed luciferase immunoprecipitation system assay. Specimens seroreactive for EBOV were confirmed by using an ELISA. Our results suggest a serologic prevalence of 2%-3.5% in the Republic of the Congo and the Democratic Republic of the Congo, which have reported outbreaks of infection with EBOV. In addition we detected a seroprevalence of 1.3% in southern Cameroon, which indicated a low risk for exposure in this region.

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Source
http://wwwnc.cdc.gov/eid/article/25/5/18-0115_article.htm
Publisher Site
http://dx.doi.org/10.3201/eid2505.180115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478206PMC
May 2019
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