Sesquiterpenes from an Eastern African Medicinal Mushroom Belonging to the Genus Sanghuangporus.

Authors:
Tian Cheng
Tian Cheng
Institute of Physics of Biological System
Clara Chepkirui
Clara Chepkirui
Department of Microbial Drugs
Cony Decock
Cony Decock
Université catholique de Louvain
Belgium
Prof. Dr. Marc Stadler, PhD
Prof. Dr. Marc Stadler, PhD
Helmholtz Centre for Infection Research
Department Head
Braunschweig, Lower Saxony | Germany

J Nat Prod 2019 Apr 19. Epub 2019 Apr 19.

Department of Microbial Drugs , Helmholtz Centre for Infection Research (HZI), and German Centre for Infection Research (DZIF) , Partner Site Hannover/Braunschweig, Inhoffenstrasse 7 , 38124 Braunschweig , Germany.

During the course of searching for new anti-infective and other biologically active secondary metabolites from Kenyan basidiomycetes, 13 previously undescribed metabolites, (6 R,7 S,10 R)-7,10-epoxy-7,11-dimethyldodec-1-ene-6,11-diol (1) and 12 sesquiterpenes named elgonenes A-L (2-13), and the known compound P-coumaric acid (14) were isolated from a basidiomycete collected in Mount Elgon Natural Reserve. The producing organism represents a new species of the genus Sanghuangporus, which is one of the segregates of the important traditional Asian medicinal mushrooms that were formerly known as the " Inonotus linteus" complex. The structure elucidation of compounds 1-13, based on 2D NMR spectroscopy, high-resolution mass spectrometry, and other spectral methods, and their antibacterial, antifungal, and cytotoxic activities are reported.

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Source
http://pubs.acs.org/doi/10.1021/acs.jnatprod.8b01086
Publisher Site
http://dx.doi.org/10.1021/acs.jnatprod.8b01086DOI Listing
April 2019
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