[Advances in isopeptide bond-mediated molecular superglue].

Authors:
Jiawen Gao
Jiawen Gao
Jiangsu Key Laboratory of Neuroregeneration and Co-innovation Center of Neuroregeneration
Xiaobao Sun
Xiaobao Sun
College of Biological & Environmental Sciences
New Brunswick | United States
Kexin Zhou
Kexin Zhou
Key Laboratory of Animal Ecology and Conservation Biology
Tietao Zhang
Tietao Zhang
Institute of Special Animal and Plant Sciences
Qian Wang, PhD
Qian Wang, PhD
Centenary Institute
Sydney, NSW | Australia

Sheng Wu Gong Cheng Xue Bao 2019 Apr;35(4):607-615

College of Biological & Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, Zhejiang, China.

Isopeptide bond-mediated molecular superglue is the irreversible covalent bond spontaneously formed by the side chains of lysine (Lys) and asparagine/aspartic acid (Asn/Asp) residues. The peptide-peptide interaction is specific, stable, and can be achieved quickly without any particular physicochemical factor. In the light of recent progress by domestic and foreign researchers, here we summarize the origin, assembly system and mechanism of isopeptide bond reaction, as well as the molecular cyclization and protein topological structure mediated by it. The prospect for its application in synthetic vaccine, hydrogel and bacterial nanobiological reactor is further discussed.

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Source
http://dx.doi.org/10.13345/j.cjb.180303DOI Listing
April 2019

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