Prospective study of gestational diabetes and fatty liver scores 9 to 16 years after pregnancy.

Authors:
Stefanie N Hinkle
Stefanie N Hinkle
National Institutes of Health
United States
Shristi Rawal
Shristi Rawal
University of Connecticut
United States
Louise G Grunnet
Louise G Grunnet
Christian Medical College
India
Jorge E Chavarro
Jorge E Chavarro
Harvard School of Public Health
United States
Allan Vaag
Allan Vaag
University of Copenhagen
Denmark
Jing Wu
Jing Wu
Jiangnan University
China
Peter Damm
Peter Damm
University of Copenhagen
Denmark

J Diabetes 2019 Apr 19. Epub 2019 Apr 19.

Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

Background: Women with gestational diabetes mellitus (GDM) may be at an increased risk of liver complications because chronic hyperglycemia is a risk factor for liver fat accumulation and potential liver dysfunction. Large prospective studies examining liver fat accumulation following a GDM pregnancy are lacking.

Methods: The Diabetes & Women's Health Study (2012-2014) examined the association between GDM and subsequent fatty liver scores among 607 women with and 619 women without GDM in the Danish National Birth Cohort. Nine to 16 years postpartum, a clinical examination was performed, with measurement of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transferase, from which fatty liver scoring indices were calculated to assess liver fat score, fatty liver index, hepatic steatosis index, and liver fat percentage. Relative risks (RR) with 95% confidence intervals (CI) for elevated liver scoring indices by GDM status were assessed adjusting for major risk factors, including prepregnancy body mass index.

Results: Women with prior GDM had higher adjusted ALT and AST levels than women without GDM (by 6.7% [95% CI 1.7-12.0] and 4.8% [95% CI 0.6-9.1], respectively). Women with GDM also had adjusted increased risks for elevated liver fat score (RR 2.34; 95% CI 1.68-3.27), fatty liver index (RR 1.59; 95% CI 1.27-1.99), and hepatic steatosis index (RR 1.44; 95% CI 1.21-1.71).

Conclusions: Women with GDM during pregnancy were at an increased risk for fatty liver 9 to 16 years postpartum. Gestational diabetes mellitus may serve as another risk indicator for the early identification and prevention of liver fat accumulation.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1753-0407.12
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http://dx.doi.org/10.1111/1753-0407.12934DOI Listing

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April 2019
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(Supplied by CrossRef)
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Younossi ZM et al.
Hepatology 2016
Non‐alcoholic fatty liver disease: epidemiology, clinical course, investigation, and treatment
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Dtsch Arztebl Int 2014
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Curr Opin Crit Care 2007

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