Prediagnostic blood levels of organochlorines and risk of non-Hodgkin lymphoma in three prospective cohorts in China and Singapore.

Authors:
Bryan A Bassig
Bryan A Bassig
National Cancer Institute
United States
Xiao-Ou Shu
Xiao-Ou Shu
Vanderbilt University School of Medicine
Nashville | United States
Andreas Sjodin
Andreas Sjodin
Centers for Disease Control and Prevention
Woon-Puay Koh
Woon-Puay Koh
Singapore
Yu-Tang Gao
Yu-Tang Gao
United States
Mark Davis
Mark Davis
Mayo Clinic
United States
Renwei Wang
Renwei Wang
University of Pittsburgh Cancer Institute
United States

Int J Cancer 2019 Apr 19. Epub 2019 Apr 19.

Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Rockville, MD.

Specific organochlorines (OCs) have been associated with non-Hodgkin lymphoma (NHL) with varying degrees of evidence. These associations have not been evaluated in Asia, where the high exposure and historical environmental contamination of certain OC pesticides (e.g., dichlorodiphenyltrichloroethane [DDT], hexachlorocyclohexane [HCH]) are different from Western populations. We evaluated NHL risk and prediagnostic blood levels of OC pesticides/metabolites and polychlorinated biphenyl congeners in a case-control study of 167 NHL cases and 167 controls nested within three prospective cohorts in Shanghai and Singapore. Conditional logistic regression was used to analyze lipid-adjusted OC levels and NHL risk. Median levels of p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), the primary DDT metabolite, and β-HCH were up to 12 and 65 times higher, respectively, in samples from the Asian cohorts compared to several cohorts in the United States and Norway. An increased risk of NHL was observed among those with higher β-HCH levels both overall (3rd vs. 1st tertile OR = 1.8, 95%CI = 1.0-3.2; p = 0.049) and after excluding cases diagnosed within 2 years of blood collection (3rd vs. 1st tertile OR = 2.0, 95%CI = 1.1-3.9; p = 0.03), and the association was highly consistent across the three cohorts. No significant associations were observed for other OCs, including p,p'-DDE. Our findings provide support for an association between β-HCH blood levels and NHL risk. This is a concern because substantial quantities of persistent, toxic residues of HCH are present in the environment worldwide. Although there is some evidence that DDT is associated with NHL, our findings for p,p'-DDE do not support an association.

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.32350DOI Listing
April 2019
3 Reads

Publication Analysis

Top Keywords

nhl risk
12
blood levels
12
non-hodgkin lymphoma
8
prospective cohorts
8
levels nhl
8
3rd 1st
8
support association
8
three prospective
8
tertile 95%ci
8
1st tertile
8
prediagnostic blood
8
nhl
7
levels
6
risk
5
cohorts
5
united states
4
cohorts united
4
cohorts compared
4
asian cohorts
4
states norway
4

References

(Supplied by CrossRef)

Similar Publications