Plasm YKL-40 Levels Are Associated with Hypertension in Patients with Obstructive Sleep Apnea.

Authors:
Kun Li
Kun Li
College of Veterinary Medicine
College Station | United States
Zhiting Chen
Zhiting Chen
Fujian Medical University Union Hospital
Quanzhou | China
Yanwen Qin
Yanwen Qin
Capital Medical University
China
Yong-Xiang Wei
Yong-Xiang Wei
Beijing Tongren Hospital
China

Biomed Res Int 2019 13;2019:5193597. Epub 2019 Mar 13.

Department of Otolaryngology, Beijing AnZhen Hospital, Capital Medical University, Beijing 100029, China.

Background: Obstructive sleep apnea (OSA) is a common disease. It can cause many serious complications. OSA may increase the risk of hypertension. However, the exact mechanism of OSA causing hypertension is not fully understood. YKL-40/chitinase-3-like protein-1 plays an important role in vascular injury, repair, and generation. We sought to explore the role of YKL-40 in endothelial dysfunction and hypertension in OSA patients.

Methods: All subjects were examined by polysomnography (PSG) and the expression of YKL-40 in the plasm of the subjects was measured by luminex. Carotid intima-media thickness (CIMT) was measured by B-mode ultrasound.

Results: According to the conditions of OSA and hypertension, we studied four groups of 157 subjects, including OSA group (OSA, N=77), OSA with hypertension group (OSA+HT, N=37), hypertension group (HT, N=20), and healthly group (Con, N=23). YKL-40 levels were significantly elevated in OSA, OSA+HT, and HT group compared to Con groups. We used the ROC to predict the sensitivity and specificity of YKL-40 in all OSA patients or all hyperpietic patients. For OSA patients, the AUC of YKL-40 is 0.807 (95% confidence interval 0.725-0.888; <0.01). For hyperpietic patients, the AUC of YKL-40 is 0.656 (95% confidence interval 0.570-0.742, =0.01). There was a significant correlation between the parameter of OSA and hypertension and YKL-40 (<0.05) and a significant correlation between Max-CIMT and YKL-40 (<0.05).

Conclusion: Elevated circulating levels of YKL-40 are associated with hypertension in OSA patients. The specificity of YKL-40 suggests that it could be a potential biomarker for OSA and hypertension.

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Source
http://dx.doi.org/10.1155/2019/5193597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436335PMC
March 2019
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