Recent Advances in Anti-virulence Therapeutic Strategies With a Focus on Dismantling Bacterial Membrane Microdomains, Toxin Neutralization, Quorum-Sensing Interference and Biofilm Inhibition.

Authors:
Marlon Henrique Cardoso
Marlon Henrique Cardoso
Centro de Análises Proteômicas e Bioquímicas
Brazil
Suzana Meira Ribeiro
Suzana Meira Ribeiro
Centro de Análises Proteômicas e Bioquímicas
Brazil
Octavio Luiz Franco
Octavio Luiz Franco
University of Brasilia
Brazil

Front Cell Infect Microbiol 2019 2;9:74. Epub 2019 Apr 2.

Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina, Universidade de Brasília, Brasília, Brazil.

Antimicrobial resistance constitutes one of the major challenges facing humanity in the Twenty-First century. The spread of resistant pathogens has been such that the possibility of returning to a pre-antibiotic era is real. In this scenario, innovative therapeutic strategies must be employed to restrict resistance. Among the innovative proposed strategies, anti-virulence therapy has been envisioned as a promising alternative for effective control of the emergence and spread of resistant pathogens. This review presents some of the anti-virulence strategies that are currently being developed, it will cover strategies focused on quench pathogen quorum sensing (QS) systems, disassemble of bacterial functional membrane microdomains (FMMs), disruption of biofilm formation and bacterial toxin neutralization.

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Source
http://dx.doi.org/10.3389/fcimb.2019.00074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454102PMC
April 2019

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