Presentation Patterns, Diagnostic Markers, Management Strategies, and Outcomes of IgD Multiple Myeloma: A Systematic Review of Literature.

Authors:
Muhammad J Khalil
Muhammad J Khalil
The University of Arizona
Mustafa N Malik
Mustafa N Malik
The University of Arizona

Cureus 2019 Feb 4;11(2):e4011. Epub 2019 Feb 4.

Internal Medicine, The University of Arizona, Tucson, USA.

Immunoglobulin (Ig) D multiple myeloma (MM) is a rare subtype of MM comprising 2% of all the cases. Malignant plasma cell invasion leads to signs and symptoms similar to other subtypes of MM. The synthesis rate of IgD is lower in IgD MM patients, making it very difficult to diagnose compared to other subtypes. As there is no available diagnostic test with 100% accuracy, the diagnosis of IgD MM is based on multiple factors. Recent advances in the treatment have resulted in a better overall survival for IgD MM patients. The aim of this systematic review was to summarize the data on presentation patterns, diagnosis modalities, management strategies, and outcomes in patients with IgD MM.

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.4011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450588PMC
February 2019

Publication Analysis

Top Keywords

strategies outcomes
8
multiple myeloma
8
igd patients
8
management strategies
8
systematic review
8
presentation patterns
8
igd
6
compared subtypes
4
diagnose compared
4
difficult diagnose
4
subtypes diagnostic
4
diagnostic test
4
accuracy diagnosis
4
100% accuracy
4
test 100%
4
making difficult
4
patients making
4
subtypes synthesis
4
symptoms subtypes
4
signs symptoms
4

Similar Publications