Deep Genome Resequencing Reveals Artificial and Natural Selection for Visual Deterioration, Plateau Adaptability and High Prolificacy in Chinese Domestic Sheep.

Authors:
Weimin Wang
Weimin Wang
College of Fisheries
Seattle | United States
Xiaoxue Zhang
Xiaoxue Zhang
University of California
United States
Xiang Zhou
Xiang Zhou
College of Chemistry and Molecular Sciences
Wuhan Shi | China
Yongfu La
Yongfu La
College of Animal Science and Technology
Yu Zhang
Yu Zhang
State Key Laboratory of Molecular Oncology
China
Chong Li
Chong Li
Institute of Biophysics
Beijing | China

Front Genet 2019 2;10:300. Epub 2019 Apr 2.

Department of Animal Sciences, Washington State University, Pullman, WA, United States.

Sheep were one of the earliest domesticated animals. Both artificial and natural selection during domestication has resulted in remarkable changes in behavioral, physiological, and morphological phenotypes; however, the genetic mechanisms underpinning these changes remain unclear, particularly for indigenous Chinese sheep. In the present study, we performed pooled whole-genome resequencing of 338 sheep from five breeds representative of indigenous Chinese breeds and compared them to the wild ancestors of domestic sheep (Asian mouflon, ) for detection of genome-wide selective sweeps. Comparative genomic analysis between domestic sheep and Asian mouflon showed that selected regions were enriched for genes involved in bone morphogenesis, growth regulation, and embryonic and neural development in domestic sheep. Moreover, we identified several vision-associated genes with funtional mutations, such as (c.G2994C/p.A982P and c.C2284A/p.L762M mutations), , and in all five Chinese native breeds. Breed-specific selected regions were determined including genes such as for hypoxia adaptability in Tibetan sheep and for heat tolerance in Duolang sheep. Our findings provide insights into the genetic mechanisms underlying important phenotypic changes that have occurred during sheep domestication and subsequent selection.

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Source
https://www.frontiersin.org/article/10.3389/fgene.2019.00300
Publisher Site
http://dx.doi.org/10.3389/fgene.2019.00300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454055PMC
April 2019
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References

(Supplied by CrossRef)
Hox genes and the evolution of vertebrate axial morphology.
Burke et al.
Development 1995
Frequency of mutations in the gene encoding the alpha subunit of rod cGMP-phosphodiesterase in autosomal recessive retinitis pigmentosa.
Dryja et al.
Invest. Ophthalmol. Vis. Sci. 1999

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