Complement in Metastasis: A Comp in the Camp.

Authors:
Daniel Ajona
Daniel Ajona
University of Navarra
Spain
Ruben Pio
Ruben Pio
University of Navarra
Spain
Fernando Lecanda
Fernando Lecanda
Adhesion and Metastasis Laboratory
Spain

Front Immunol 2019 3;10:669. Epub 2019 Apr 3.

Program in Solid Tumors, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.

The complement system represents a pillar of the innate immune response. This system, critical for host defense against pathogens, encompasses more than 50 soluble, and membrane-bound proteins. Emerging evidence underscores its clinical relevance in tumor progression and its role in metastasis, one of the hallmarks of cancer. The multistep process of metastasis entails the acquisition of advantageous functions required for the formation of secondary tumors. Thus, targeting components of the complement system could impact not only on tumor initiation but also on several crucial steps along tumor dissemination. This novel vulnerability could be concomitantly exploited with current strategies overcoming tumor-mediated immunosuppression to provide a substantial clinical benefit in the treatment of metastatic disease. In this review, we offer a on recent advances in this area and their prospective potential for cancer treatment.

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Source
https://www.frontiersin.org/article/10.3389/fimmu.2019.00669
Publisher Site
http://dx.doi.org/10.3389/fimmu.2019.00669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457318PMC
April 2019
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