Blood mercury, lead, cadmium, manganese and selenium levels in pregnant women and their determinants: the Japan Environment and Children's Study (JECS).

Authors:
Shoji F Nakayama
Shoji F Nakayama
Dalian University of Technology
China
Tomoko Oguri
Tomoko Oguri
The University of Tokyo
Japan
Tomohiko Isobe
Tomohiko Isobe
Ehime University
Japan
Ayano Takeuchi
Ayano Takeuchi
National Institute for Environmental Studies
Japan
Yayoi Kobayashi
Yayoi Kobayashi
National Institute for Environmental Studies
Takehiro Michikawa
Takehiro Michikawa
School of Medicine
Japan
Shin Yamazaki
Shin Yamazaki
School of Public Health in the Graduate School of Medicine
Aurora | United States

J Expo Sci Environ Epidemiol 2019 Apr 18. Epub 2019 Apr 18.

Japan Environment and Children's Study Programme Office, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki, 305-8506, Japan.

The Japan Environment and Children's Study (JECS) is a birth-cohort study of 100,000 mother-child dyads that aims to investigate the effect of the environment on child health and development. Mercury (Hg), lead (Pb), cadmium (Cd), manganese (Mn) and selenium (Se) are considered to be important co-exposures when examining the effect of other chemical substances on child development. The levels of these elements in the blood of 20,000 randomly selected mid/late-term pregnant women from the whole JECS cohort were analysed using inductively coupled plasma-mass spectrometry. The median concentrations (interquartile ranges) for Pb, Hg, Cd, Mn and Se were 0.63 (0.51-0.78) µg dl, 3.83 (2.70-5.43) µg l, 0.70 (0.52-0.95) µg l, 16.1 (13.2-19.6) µg l and 178 (165-192) µg l, respectively. Hg and Se correlated positively with each other (Spearman's ρ = 0.287), as did Pb and Cd (ρ = 0.239) and Cd and Mn (ρ = 0.267). The blood Pb levels decreased by 5-10-fold over the past 25 years. The main predictors of the blood levels of each element were fish consumption for Hg, maternal age and non-alcoholic beverage consumption for Pb, maternal age and smoking for Cd, gestational age at sampling for Mn and serum protein levels for Se. These results revealed the historical trends and current predictors of the blood levels of these elements in pregnant Japanese women.

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Source
http://dx.doi.org/10.1038/s41370-019-0139-0DOI Listing
April 2019

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