Insights into rheumatic diseases from next-generation sequencing.

Authors:
Laura T Donlin
Laura T Donlin
Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center
Sung-Ho Park
Sung-Ho Park
Hallym University Sacred Heart Hospital
Eugenia Giannopoulou
Eugenia Giannopoulou
Weill Cornell Medical College
United States
Aleksandra Ivovic
Aleksandra Ivovic
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Bethesda | United States
Kyung-Hyun Park-Min
Kyung-Hyun Park-Min
Hospital for Special Surgery
United States
Richard M Siegel
Richard M Siegel
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Lionel B Ivashkiv
Lionel B Ivashkiv
Hospital for Special Surgery
United States

Nat Rev Rheumatol 2019 Jun;15(6):327-339

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, USA.

Rheumatic diseases have complex aetiologies that are not fully understood, which makes the study of pathogenic mechanisms in these diseases a challenge for researchers. Next-generation sequencing (NGS) and related omics technologies, such as transcriptomics, epigenomics and genomics, provide an unprecedented genome-wide view of gene expression, environmentally responsive epigenetic changes and genetic variation. The integrated application of NGS technologies to samples from carefully phenotyped clinical cohorts of patients has the potential to solve remaining mysteries in the pathogenesis of several rheumatic diseases, to identify new therapeutic targets and to underpin a precision medicine approach to the diagnosis and treatment of rheumatic diseases. This Review provides an overview of the NGS technologies available, showcases important advances in rheumatic disease research already powered by these technologies and highlights NGS approaches that hold particular promise for generating new insights and advancing the field.

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Source
http://dx.doi.org/10.1038/s41584-019-0217-7DOI Listing
June 2019

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