Allosteric regulation of AMP-activated protein kinase by adenylate nucleotides and small-molecule drugs.

Biochem Soc Trans 2019 Apr 18;47(2):733-741. Epub 2019 Apr 18.

Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia

The AMP (adenosine 5'-monophosphate)-activated protein kinase (AMPK) is a key regulator of cellular and whole-body energy homeostasis that co-ordinates metabolic processes to ensure energy supply meets demand. At the cellular level, AMPK is activated by metabolic stresses that increase AMP or adenosine 5'-diphosphate (ADP) coupled with falling adenosine 5'-triphosphate (ATP) and acts to restore energy balance by choreographing a shift in metabolism in favour of energy-producing catabolic pathways while inhibiting non-essential anabolic processes. AMPK also regulates systemic energy balance and is activated by hormones and nutritional signals in the hypothalamus to control appetite and body weight. Failure to maintain energy balance plays an important role in chronic diseases such as obesity, type 2 diabetes and inflammatory disorders, which has prompted a major drive to develop pharmacological activators of AMPK. An array of small-molecule allosteric activators has now been developed, several of which can activate AMPK by direct allosteric activation, independently of Thr172 phosphorylation, which was previously regarded as indispensable for AMPK activity. In this review, we summarise the state-of-the-art regarding our understanding of the molecular mechanisms that govern direct allosteric activation of AMPK by adenylate nucleotides and small-molecule drugs.

Download full-text PDF

Source
http://www.biochemsoctrans.org/lookup/doi/10.1042/BST2018062
Publisher Site
http://dx.doi.org/10.1042/BST20180625DOI Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
April 2019
11 Reads

Publication Analysis

Top Keywords

energy balance
12
amp adenosine
8
adenylate nucleotides
8
small-molecule drugs
8
nucleotides small-molecule
8
protein kinase
8
allosteric activation
8
direct allosteric
8
ampk
7
energy
5
control appetite
4
hypothalamus control
4
hormones nutritional
4
signals hypothalamus
4
nutritional signals
4
body weight
4
plays role
4
role chronic
4
chronic diseases
4
diseases obesity
4

Altmetric Statistics

References

(Supplied by CrossRef)

Similar Publications