APC/C Ubiquitin Ligase: Coupling Cellular Differentiation to G1/G0 Phase in Multicellular Systems.

Authors:
Yuu Kimata
Yuu Kimata
Marie Curie Research Institute
United Kingdom

Trends Cell Biol 2019 Apr 15. Epub 2019 Apr 15.

School of Life Science and Technology, ShanghaiTech University, Shanghai, China; University of Cambridge, Cambridge, UK. Electronic address:

The anaphase-promoting complex/cyclosome (APC/C) is an evolutionarily conserved ubiquitin ligase that controls cell cycle progression through spatiotemporally regulated proteolysis. Although recent studies revealed its postmitotic function, our knowledge of the role of APC/C beyond cell cycle regulation in the biology of multicellular organisms is far from complete. Here, I review recent advances in the function of APC/C in animal development, specifically focusing on its emerging role in regulating cell differentiation. I describe how APC/C regulates distinct processes during the course of differentiation by deploying diverse molecular machineries in a variety of developmental contexts. Also, I discuss the significance and clinical relevance of the unique capacity of APC/C and other cell cycle regulators to couple distinct cellular processes with cell proliferation control.

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http://dx.doi.org/10.1016/j.tcb.2019.03.001DOI Listing
April 2019
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