Structure-activity relationship study of antitrypanosomal chalcone derivatives using multivariate analysis.

Bioorg Med Chem Lett 2019 Jun 12;29(12):1459-1462. Epub 2019 Apr 12.

Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, SP 09210-580, Brazil. Electronic address:

Chagas disease represents one of several neglected diseases with a reduced number of chemotherapeutical drugs including the highly toxic compounds benznidazole and nifurtimox. In this sense, natural products represent an import scaffold for the discovery of new biologically active compounds, in which chalcones are promising representatives due to their antitrypanosomal potential. In this work, a series of 36 chalcone derivatives were synthesized and tested against trypomastigotes of Trypanosoma cruzi. In addition, a detailed investigation on their molecular features was performed. The obtained results suggest that certain molecular features are fundamental for an efficient antitrypanosomal potential of chalcones, such as allylic groups, α,β-unsaturated carbonyl system, and aromatic hydroxyl groups. These results were obtained based on the interpretation of machine-learning and multivariate statistical methods, which revealed the essential characteristics of chalcone prototypes against trypomastigotes of T. cruzi.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X193024
Publisher Site
http://dx.doi.org/10.1016/j.bmcl.2019.04.020DOI Listing

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June 2019
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