Prevalence, types, and malformations in congenital anomalies of the kidney and urinary tract in newborns: a retrospective hospital-based study.

Authors:
Zhong-Yi Li
Zhong-Yi Li
Dalian University of Technology
China
Li-Qian Qiu
Li-Qian Qiu
Zhejiang University
China
Dan-Qing Chen
Dan-Qing Chen
Zhejiang University
China
Jian-Yun Xu
Jian-Yun Xu
Women's Hospital
Ahmedabad | India
Xiao-Hui Zhang
Xiao-Hui Zhang
Peking University People's Hospital
China

Ital J Pediatr 2019 Apr 18;45(1):50. Epub 2019 Apr 18.

Department of Women's Health, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, Zhejiang Province, 310006, People's Republic of China.

Background: Congenital anomalies of the kidney and urinary tract (CAKUTs) are some of the most common birth defects affecting newborns. CAKUTs often have poor birth outcomes owing to the limited experience of physicians in developing countries regarding antenatal and postnatal diagnosis. We aimed to estimate the epidemiology of CAKUTs using data from a hospital-based registry in Zhejiang Province, China.

Methods: We included a total of 2790 newborns with CAKUTs, identified among 1,748,038 births during 2010-2016. The prevalence and type of CAKUTs, maternal and neonatal characteristics, and associated malformations were analyzed.

Results: The average prevalence of CAKUTs born to mothers overall and mothers aged ≥35 years were both around 1.60 per 1000 births (95% confidence interval (CI), 1.54-1.66; 95% CI, 1.44-1.83, respectively) during the study period. The prevalence of CAKUTs changed over time among all women and women of advanced maternal age, although no significant trends were observed. CAKUTs were more likely to occur in male than female newborns (odds ratio (OR) 1.28, 95% CI 1.18-1.38), in multiple births than singletons (OR 1.53, 95% CI 1.21-1.92) and in urban areas than rural areas (OR 1.27, 95% CI 1.18-1.37). The overall prenatal detection rate of CAKUTs was 73.87%. The average gestational age at antenatal diagnosis was 26.57 ± 8.70 weeks. A total 22.69% CAKUTs had associated malformations. Congenital heart defects were the most common anomalies, accounting for 8.89% of the whole population. The main proportion in subgroups was hydronephrosis, representing 31.79% of registered CAKUTs.

Conclusions: There was a nearly twofold increase in the prevalence of CAKUTs from 2010 to 2016 in Zhejiang Province. CAKUTs are strongly associated with male sex, multiple births, urban areas, and other nonurinary congenital malformations.

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13052-019-0635-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472003PMC
April 2019

Publication Analysis

Top Keywords

prevalence cakuts
12
cakuts
12
anomalies kidney
8
kidney urinary
8
multiple births
8
urinary tract
8
zhejiang province
8
congenital anomalies
8
associated malformations
8
malformations congenital
8
cakuts associated
8
newborns cakuts
8
urban areas
8
prevalence
5
95%
5
95% 121-192
4
occur male
4
153 95%
4
cakuts occur
4
observed cakuts
4

References

(Supplied by CrossRef)
Article in Birth Defects Res A Clin Mol Teratol
VA Postoev et al.
Birth Defects Res A Clin Mol Teratol 2016
Article in Urol Ann
NS Bondagji et al.
Urol Ann 2014
Article in Arch Dis Child
L Andrés-Jensen et al.
Arch Dis Child 2016
Article in Medicine (Baltimore)
YL Tain et al.
Medicine (Baltimore) 2016
Article in Birth Defects Res.
H Laurichesse Delmas et al.
Birth Defects Res. 2017
Article in J Perinatol
P Danziger et al.
J Perinatol 2016
Article in Eur J Pediatr
S Nef et al.
Eur J Pediatr 2016
Article in Semin Fetal Neonatal Med
S Rosenblum et al.
Semin Fetal Neonatal Med 2017
Article in Clin Exp Nephrol
M Hattori et al.
Clin Exp Nephrol 2015
Article in J Urol
P Marzuillo et al.
J Urol 2017
Article in Eur J Med Genet
C Stoll et al.
Eur J Med Genet 2014

Similar Publications