Sero-epidemiological status and risk factors of toxoplasmosis in pregnant women in Northern Vietnam.

Authors:
Dung Trung Do
Dung Trung Do
Research Institute for Aquaculture No. 1
Vietnam
Niko Speybroeck
Niko Speybroeck
Institute of Health and Society (IRSS)
Belgium
Brecht Devleesschauwer
Brecht Devleesschauwer
Institute of Health and Society (IRSS)
Belgium
Elizaveta Padalko
Elizaveta Padalko
Ghent University Hospital
Belgium

BMC Infect Dis 2019 Apr 18;19(1):329. Epub 2019 Apr 18.

Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.

Background: In Vietnam, few studies have determined the epidemiological status of toxoplasmosis in pregnant women and no routine prenatal screening is in place. This study was conducted to evaluate the seroprevalence of this zoonotic parasitic infection in pregnant women in Northern Vietnam and to assess the association with awareness, risk factors and congenital toxoplasmosis.

Methods: Approximately 800 pregnant women were included in the study from two hospitals, one in Hanoi and one in Thai Binh province, which is known to have a dense cat population. Serological immunoglobulin G (IgG) and immunoglobulin M (IgM) detection was performed to estimate the seroprevalence of toxoplasmosis and sero-incidence of maternal and congenital toxoplasmosis. In addition, a survey was conducted about awareness, clinical history, presentation of signs and symptoms relating to toxoplasmosis and to detect biologically plausible and socio-demographic risk factors associated with toxoplasmosis. Associations with seroprevalence were assessed using univariable and multivariable analysis.

Results: The mean IgG seroprevalence after the full diagnostic process was 4.5% (95% confidence interval(CI): 2.7-7.0) and 5.8% (95% CI: 3.7-8.6) in Hanoi and Thai Binh hospital, respectively, and included one seroconversion diagnosed in Thai Binh hospital. Only 2.0% of the pregnant women in Hanoi hospital and 3.3% in Thai Binh hospital had heard about toxoplasmosis before this study.

Conclusion: Since the percentage of seronegative, and thus susceptible, pregnant women was high and the awareness was low, we suggest to distribute information about toxoplasmosis and its prevention among women of child bearing age. Furthermore, future studies are recommended to investigate why such a low seroprevalence was seen in pregnant women in Northern Vietnam compared to other countries in South East Asia and globally.

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Source
https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
Publisher Site
http://dx.doi.org/10.1186/s12879-019-3885-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471880PMC
April 2019
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References

(Supplied by CrossRef)
Article in Zoonoses Public Health
E Petersen et al.
Zoonoses Public Health 2010
Article in Foodborne Pathog Dis
BT Cenci-Goga et al.
Foodborne Pathog Dis 2011
Article in Trans R Soc Trop Med Hyg
H Caballero-Ortega et al.
Trans R Soc Trop Med Hyg 2012
Article in Zoonoses Public Hlth
HA Dabritz et al.
Zoonoses Public Hlth 2010
Article in PLoS Negl Trop Dis
JE Gómez-Marin et al.
PLoS Negl Trop Dis 2011
Article in Parasitol Res
JM Ramos et al.
Parasitol Res 2011
Article in Clin Microbiol Rev
F Robert-Gangneux et al.
Clin Microbiol Rev 2012
Article in Bone Marrow Transpl
A Mele et al.
Bone Marrow Transpl 2002
Article in PLoS Med
PR Torgerson et al.
PLoS Med 2015
Article in Scand J Infect Dis
WK Wong et al.
Scand J Infect Dis 2013
Article in Clin Infect Dis
AH Havelaar et al.
Clin Infect Dis 2007

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